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Type: Journal article
Title: The molecular interactions of ZIKV and DENV with the type-i IFN response
Author: Coldbeck-Shackley, R.C.
Eyre, N.S.
Beard, M.R.
Citation: Vaccines, 2020; 8(3):530-1-530-21
Publisher: MDPI
Issue Date: 2020
ISSN: 2076-393X
Statement of
Rosa C. Coldbeck-Shackley, Nicholas S. Eyre and Michael R. Beard
Abstract: Zika Virus (ZIKV) and Dengue Virus (DENV) are related viruses of the Flavivirus genus that cause significant disease in humans. Existing control measures have been ineffective at curbing the increasing global incidence of infection for both viruses and they are therefore prime targets for new vaccination strategies. Type-I interferon (IFN) responses are important in clearing viral infection and for generating efficient adaptive immune responses towards infection and vaccination. However, ZIKV and DENV have evolved multiple molecular mechanisms to evade type-I IFN production. This review covers the molecular interactions, from detection to evasion, of these viruses with the type-I IFN response. Additionally, we discuss how this knowledge can be exploited to improve the design of new vaccine strategies.
Keywords: ZIKV; DENV; innate immunity; interferon; IFN; evasion
Rights: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (
DOI: 10.3390/vaccines8030530
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Appears in Collections:Aurora harvest 4
Molecular and Biomedical Science publications

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