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https://hdl.handle.net/2440/133236
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Type: | Journal article |
Title: | Investigation of peripheral complement factors across stages of psychosis |
Author: | Laskaris, L. Zalesky, A. Weickert, C.S. Di Biase, M.A. Chana, G. Baune, B.T. Bousman, C. Nelson, B. McGorry, P. Everall, I. Pantelis, C. Cropley, V. |
Citation: | Schizophrenia Research, 2019; 204:30-37 |
Publisher: | Elsevier |
Issue Date: | 2019 |
ISSN: | 0920-9964 1573-2509 |
Statement of Responsibility: | Liliana Laskaris, Andrew Zalesky, Cynthia Shannon Weickert, Maria A.Di Biase, Gursharan Chana, Bernhard T.Baune ... et al. |
Abstract: | The complement cascade has been proposed to contribute to the pathogenesis of schizophrenia. However, it remains unclear whether peripheral complement levels differ in cases compared to controls, change over the course of illness and whether they are associated with current symptomatology. This study aimed to: i) investigate whether peripheral complement protein levels are altered at different stages of illness, and ii) identify patterns among complement protein levels that predict clinical symptoms. Complement factors C1q, C3 and C4 were quantified in 183 participants [n = 83 Healthy Controls (HC), n = 10 Ultra-High Risk (UHR) for psychosis, n = 40 First Episode Psychosis (FEP), n = 50 Chronic schizophrenia] using Multiplex ELISA. Permutation-based t-tests were used to assess between-group differences in complement protein levels at each of the three illness stages, relative to age- and gender-matched healthy controls. Canonical correlation analysis was used to identify patterns of complement protein levels that correlated with clinical symptoms. C4 was significantly increased in chronic schizophrenia patients, while C3 and C4 were significantly increased in UHR patients. There were no differences in C1q, C3 and C4 in FEP patients when adjusting for BMI. A molecular pattern of increased C4 and decreased C3 was associated with positive and negative symptom severity in the pooled patient sample. Our findings indicate that peripheral complement concentration is increased across specific stages of psychosis and its imbalance may be associated with symptom severity. Given the small sample size of the UHR group, these findings should be regarded as exploratory, requiring replication. |
Keywords: | Biomarkers Complement protein Psychosis Schizophrenia |
Rights: | © 2018 Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.schres.2018.11.035 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1065742 http://purl.org/au-research/grants/nhmrc/601253 http://purl.org/au-research/grants/nhmrc/628386 http://purl.org/au-research/grants/nhmrc/1105825 http://purl.org/au-research/grants/nhmrc/1117079 |
Published version: | http://dx.doi.org/10.1016/j.schres.2018.11.035 |
Appears in Collections: | Psychiatry publications |
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