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https://hdl.handle.net/2440/136053
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Type: | Journal article |
Title: | Elucidating the pharmacokinetics/pharmacodynamics of aerosolized colistin against multidrug-resistant acinetobacter baumannii and klebsiella pneumoniae in a mouse lung infection model |
Author: | Lin, Y.W. Zhou, Q.T. Han, M.L. Chen, K. Onufrak, N.J. Wang, J. Turnidge, J.D. Howden, B.P. Forrest, A. Chan, H.K. Li, J. |
Citation: | Antimicrobial Agents and Chemotherapy, 2018; 62(2):e01790-1-e0179-17 |
Publisher: | American Society for Microbiology |
Issue Date: | 2018 |
ISSN: | 0066-4804 1098-6596 |
Statement of Responsibility: | Yu-Wei Lin, Qi Tony Zhou, Mei-Ling Han, Ke Chen, Nikolas J. Onufrak, Jiping Wang, John D. Turnidge, Benjamin P. Howden, Alan Forrest, Hak-Kim Chan, Jian Lih |
Abstract: | The pharmacokinetics/pharmacodynamics (PK/PD) of aerosolized colistin was investigated against Acinetobacter baumannii and Klebsiella pneumoniae over 24 h in a neutropenic mouse lung infection model. Dose fractionation studies were performed over 2.64 to 23.8 mg/kg/day, and the data were fitted to a sigmoid inhibitory model. The area under the concentration-time curve over 24 h in the steady state divided by the MIC (AUC/MIC) in the epithelial lining fluid was the most predictive PK/PD index for aerosolized colistin against both pathogens. Our study provides important pharmacological information for optimizing aerosolized colistin. |
Keywords: | polymyxin; respiratory tract infections; pulmonary administration; Acinetobacter baumannii; Klebsiella pneumoniae; Gram-negative bacteria |
Rights: | © 2018 American Society for Microbiology. All Rights Reserved. |
DOI: | 10.1128/AAC.01790-17 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1065046 |
Published version: | http://dx.doi.org/10.1128/aac.01790-17 |
Appears in Collections: | Medical Sciences publications |
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