Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/138390
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Type: | Journal article |
Title: | Changes in lipids and inflammatory markers after consuming diets high in red meat or dairy for four weeks |
Author: | Turner, K.M. Keogh, J.B. Meikle, P.J. Clifton, P.M. |
Citation: | Nutrients, 2017; 9(8):886-1-886-11 |
Publisher: | MDPI AG |
Issue Date: | 2017 |
ISSN: | 2072-6643 2072-6643 |
Statement of Responsibility: | Kirsty M. Turner, Jennifer B. Keogh, Peter J. Meikle and Peter M. Clifton |
Abstract: | There is a body of evidence linking inflammation, altered lipid metabolism, and insulin resistance. Our previous research found that insulin sensitivity decreased after a four-week diet high in dairy compared to a control diet and to one high in red meat. Our aim was to determine whether a relationship exists between changes in insulin sensitivity and inflammatory biomarkers, or with lipid species. Fasting Tumor Necrosis Factor alpha (TNF-α), Tumor Necrosis Factor Receptor II (sTNF-RII), C-reactive protein (CRP), and lipids were measured at the end of each diet. TNF-α and the ratio TNF-α/sTNF-RII were not different between diets and TNF-α, sTNF-RII, or the ratio TNF-α/sTNF-RII showed no association with homeostasis model assessment-estimated insulin resistance (HOMA-IR). A number of phosphatidylethanolamine (PE) and phosphatidylinositol (PI) species differed between dairy and red meat and dairy and control diets, as did many phosphatidylcholine (PC) species and cholesteryl ester (CE) 14:0, CE15:0, lysophosphatidylcholine (LPC) 14:0, and LPC15:0. None had a significant relationship (p = 0.001 or better) with log homeostasis model assessment-estimated insulin resistance (HOMA-IR), although LPC14:0 had the strongest relationship (p = 0.004) and may be the main mediator of the effect of dairy on insulin sensitivity. LPC14:0 and the whole LPC class were correlated with CRP. The correlations between dietary change and the minor plasma phospholipids PI32:1 and PE32:1 are novel and may reflect significant changes in membrane composition. Inflammatory markers were not altered by changes in protein source while the correlation of LPC with CRP confirms a relationship between changes in lipid profile and inflammation. |
Keywords: | red meat; dairy; insulin resistance; lipids; inflammation |
Description: | Published: 17 August 2017 |
Rights: | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
DOI: | 10.3390/nu9080886 |
Published version: | http://dx.doi.org/10.3390/nu9080886 |
Appears in Collections: | Molecular and Biomedical Science publications |
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