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Type: Journal article
Title: The influence of the renin angiotensin system on abnormal expression of nerve growth factor in the spontaneously hypertensive rat.
Author: Jeffreson, S.
Rush, R.
Zettler, C.
Frewin, D.
Head, R.
Citation: Clinical and Experimental Pharmacology and Physiology, 1995; 22(6-7):478-480
Publisher: Blackwell
Issue Date: 1995
ISSN: 0305-1870
Statement of
S. Jeffreson, R. Rush, C. Zettler, D. B. Frewin and R. J. Head
Abstract: 1. The levels of the neurotrophic factor, nerve growth factor (NGF) in the mesenteric vascular bed of the spontaneously hypertensive rat (SHR) were greater than those in the corresponding vascular bed of normotensive Wistar-Kyoto rats (WKY). 2. Administration of angiotensin II (200 ng/kg per min, by minipump) for 2 weeks to juvenile WKY rats increased the levels of NGF in the mesenteric vasculature to those seen in untreated SHR. 3. Administration of the angiotensin II receptor antagonists losartan (30 mg/kg per day, p.o.) or PD144277 (10 mg/kg per day, p.o.) to juvenile SHR for 4 weeks reduced the levels of NGF such that they were indistinguishable from the values obtained for normotensive WKY rats. 4. The results confirm the elevated level of NGF in the mesenteric vasculature of the SHR and suggest that angiotensin II may play a role in regulating the abnormal concentrations of the protein in this tissue.
Keywords: angiotensin II
mesenteric vascular bed
nerve growth factor, spontaneously hypertensive rat
Wistar-Kyoto rat
DOI: 10.1111/j.1440-1681.1995.tb02050.x
Appears in Collections:Aurora harvest 7
Pharmacology publications

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