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https://hdl.handle.net/2440/14364
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DC Field | Value | Language |
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dc.contributor.author | Dyer, S. | - |
dc.contributor.author | de la Lande, I. | - |
dc.contributor.author | Frewin, D. | - |
dc.contributor.author | Head, R. | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | Clinical and Experimental Pharmacology and Physiology, 1998; 25(3-4):246-251 | - |
dc.identifier.issn | 0305-1870 | - |
dc.identifier.issn | 1440-1681 | - |
dc.identifier.uri | http://hdl.handle.net/2440/14364 | - |
dc.description | Article first published online: 9 OCT 2008 | - |
dc.description.abstract | 1. 5-Hydroxytryptamine (5-HT) exerts both contractile and relaxant effects in the marmoset isolated aorta, actions that are unaffected by the 5-HT[sub 2] antagonist ketanserin. The aim of the present study was to define the receptors mediating the contractile activity of 5-HT in the marmoset aorta. 2. Contractile responses were elicited in aortic rings that were either: (i) precontracted submaximally with the thromboxane A[sub 2] agonist U44069 in order to amplify the responses; or (ii) exposed to N[sup ω]-nitro-L-arginine (100 µmol/L) plus LY53857 (0.1 µmol/L; a 5-HT[sub 2] receptor antagonist shown previously to inhibit relaxation). The effect of 5-HT on adenosine 3',5'-cyclic monophosphate (cAMP) formation was also investigated. 3. The effects of agonists and antagonists comprised: (i) agonist potencies in the order 5-carboxamidotryptamine > 5-HT > sumatriptan > 8-hydroxy-2-(di-n-propylamino)tetralin; (ii) inhibition of contractile action of 5-HT by the 5-HT[sub 1D] antagonist GR 127935; (iii) a contractile response to methysergide; (iv) a lack of effect of tropisetron, an antagonist of 5-HT[sub 3] and 5-HT[sub 4] receptors; and (v) inhibition of forskolin-stimulated cAMP formation by 5-HT (in the presence of LY 53857), indicative of negative coupling to adenylate cyclase. 4. The above effects fulfil the criteria for a 5-HT[sub 1]-like receptor. In view of the previous finding that this contractile response is insensitive to ketanserin, it is concluded that the contractile effects of 5-HT in the marmoset aorta are mediated exclusively by a 5-HT[sub 1]-like receptor. | - |
dc.description.statementofresponsibility | S M Dyer, I S de la Lande, D B Frewin and R J Head | - |
dc.language.iso | en | - |
dc.publisher | BLACKWELL SCIENCE | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1440-1681.1998.t01-13-.x | - |
dc.subject | Arteries | - |
dc.subject | Aorta | - |
dc.subject | Animals | - |
dc.subject | Callithrix | - |
dc.subject | Serotonin | - |
dc.subject | Prostaglandin Endoperoxides, Synthetic | - |
dc.subject | Receptors, Serotonin | - |
dc.subject | Cyclic AMP | - |
dc.subject | Vasoconstriction | - |
dc.title | 5-hydroxytryptamine-induced contraction of the marmoset aorta is mediated by a 5-HT-1 like receptor. | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1440-1681.1998.t01-13-.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Head, R. [0000-0002-1196-0926] | - |
Appears in Collections: | Aurora harvest 7 Pharmacology publications |
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