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https://hdl.handle.net/2440/14430
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dc.contributor.author | Somogyi, A. | - |
dc.contributor.author | Reinhard, H. | - |
dc.contributor.author | Bochner, F. | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | European Journal of Clinical Pharmacology, 1996; 50(5):417-419 | - |
dc.identifier.issn | 0031-6970 | - |
dc.identifier.issn | 1432-1041 | - |
dc.identifier.uri | http://hdl.handle.net/2440/14430 | - |
dc.description.abstract | <h4>Objective</h4>To examine the effects of omeprazole and cimetidine on the urinary recovery and metabolic ratio of proguanil in healthy subjects.<h4>Methods</h4>A metabolic interaction study was conducted in 12 young, healthy extensive metabolisers of proguanil, a CYP2C19 substrate, following a single 100 mg oral dose by analysis of urine collected for 8 hours.<h4>Results</h4>Concomitant administration of omeprazole (20 mg), a CYP2C19 substrate, had no significant effect on the urinary recovery of proguanil or cycloguanil, or the ratio of cycloguanil to proguanil [mean 0.76 (95% CI: 0.53 to 0.98) proguanil alone; mean 0.65 (95% CI: 0.40 to 0.89) proguanil plus omeprazole]. In contrast, cimetidine (400 mg), a general CYP inhibitor and renal organic cation secretion inhibitor, decreased the urinary recovery of cycloguanil and reduced the metabolic ratio from a mean of 0.76 to 0.54 (P < 0.01). In 3 poor metabolisers of proguanil, cimetidine had no effect on the proguanil metabolic ratio.<h4>Conclusion</h4>The concomitant administration of omeprazole or cimetidine will not result in phenocopying extensive metabolisers of proguanil, although cimetidine inhibits the formation of cycloguanil in extensive metabolisers. | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER VERLAG | - |
dc.source.uri | http://dx.doi.org/10.1007/s002280050133 | - |
dc.subject | Humans | - |
dc.subject | Cimetidine | - |
dc.subject | Triazines | - |
dc.subject | Omeprazole | - |
dc.subject | Cytochrome P-450 Enzyme System | - |
dc.subject | Aryl Hydrocarbon Hydroxylases | - |
dc.subject | Mixed Function Oxygenases | - |
dc.subject | Enzyme Inhibitors | - |
dc.subject | Adult | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Proguanil | - |
dc.subject | Cytochrome P-450 CYP2C19 | - |
dc.title | Effect of omeprazole and cimetidine on the urinary metabolic ratio of proguanil in volunteers. | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/s002280050133 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Somogyi, A. [0000-0003-4779-0380] | - |
Appears in Collections: | Aurora harvest 2 Pharmacology publications |
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