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Type: Journal article
Title: Role of endogenous adenosine in the expression of opiate withdrawal in rats.
Author: Salem, A.
Hope, W.
Citation: European Journal of Pharmacology, 1999; 369(1):39-42
Issue Date: 1999
ISSN: 0014-2999
Abstract: Samples of extracellular fluid from striatum and nucleus accumbens of anaesthetised rats undergoing opiate withdrawal were collected using microdialysis and then analysed for adenosine and its metabolites using high performance liquid chromatography (HPLC) and ultraviolet (UV) detection. Although the amount of adenosine present in the dialysate from either brain region was below the limit of detection by 90 min after probe placement, the metabolites could still be detected. Samples of dialysates collected from the nucleus accumbens contained significantly higher concentrations of hypoxanthine and inosine following naloxone challenge. The data are compatible with the hypothesis that endogenous adenosine might be involved in the expression of the opiate abstinence syndrome.
Keywords: Corpus Striatum; Nucleus Accumbens; Animals; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Naloxone; Hypoxanthine; Adenosine; Inosine; Narcotics; Narcotic Antagonists; Chromatography, High Pressure Liquid; Microdialysis; Male
RMID: 0030003405
DOI: 10.1016/S0014-2999(99)00046-1
Appears in Collections:Pharmacology publications

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