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https://hdl.handle.net/2440/14480
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DC Field | Value | Language |
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dc.contributor.author | Salem, A. | - |
dc.contributor.author | Hope, W. | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | Journal of Pharmacological and Toxicological Methods, 1999; 40(3):159-164 | - |
dc.identifier.issn | 1056-8719 | - |
dc.identifier.issn | 1873-488X | - |
dc.identifier.uri | http://hdl.handle.net/2440/14480 | - |
dc.description.abstract | This study was performed to measure absorption of morphine from the injection site following treatment of rats with slow-release emulsions formulated with morphine hydrochloride and morphine base. Samples of emulsion were collected from the injection site of halothane anesthetized animals at 24 and 48 h following emulsion treatment and concentrations of morphine remaining in the emulsion were analyzed using high-performance liquid chromatography (HPLC). In another group of morphine-treated rats, at times equivalent to collecting samples of emulsion, the intensity of naloxone-precipitated withdrawal behaviors was monitored. Both morphine base- and hydrochloride-containing emulsions induced a high degree of physical dependence in animals treated over 48 h. Release of morphine from emulsions containing morphine base was slower than that from the hydrochloride formulations. In the 24-h morphine base-treated animals, approximately 45% was absorbed from the injection site as opposed to 99% in the 24-h morphine hydrochloride-treated animals. These results suggest that morphine base containing emulsions provide a more sustained exposure to the opioid. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.source.uri | http://dx.doi.org/10.1016/s1056-8719(98)00050-1 | - |
dc.subject | Feces | - |
dc.subject | Animals | - |
dc.subject | Rats | - |
dc.subject | Rats, Wistar | - |
dc.subject | Morphine Dependence | - |
dc.subject | Body Weight | - |
dc.subject | Morphine | - |
dc.subject | Emulsions | - |
dc.subject | Delayed-Action Preparations | - |
dc.subject | Chromatography, High Pressure Liquid | - |
dc.subject | Administration, Cutaneous | - |
dc.subject | Female | - |
dc.title | Absorption of morphine from a slow-release emulsion used to induce morphine dependence in rats. | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S1056-8719(98)00050-1 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Salem, A. [0000-0002-4555-9794] | - |
Appears in Collections: | Aurora harvest 2 Pharmacology publications |
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