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https://hdl.handle.net/2440/14553
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dc.contributor.author | Abeywardena, M. | - |
dc.contributor.author | Jablonskis, L. | - |
dc.contributor.author | Head, R. | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Prostaglandins, Leukotrienes and Essential Fatty Acids, 2001; 64(4&5):281-287 | - |
dc.identifier.issn | 0952-3278 | - |
dc.identifier.issn | 1532-2823 | - |
dc.identifier.uri | http://hdl.handle.net/2440/14553 | - |
dc.description.abstract | Recent reports suggest modulation of chronic obstructive pulmonary disease by dietary polyunsaturated fatty acids. In the present study, we re-examined this possibility by using an established animal model of pulmonary sensitisation. Adult guinea pigs were fed diets supplemented (10% w/w) with either olive, canola or safflower oil for 4 weeks before sensitising with ovalbumin and continuing on various diets for a further 6 week period. Neither the contraction following ovalbumin challenge, nor the responses to histamine, carbachol and various eicosanoid mediators – prostaglandin F2α, leukotriene C4, thromboxane mimetic U44619 – of isolated segments of airway tissue were altered (P>0.05, ANOVA) by the dietary lipid treatment. Lipid analysis showed changes in membrane linoleic acid (18:2n-6) and α -linolenic acids (α 18:3n-3) in lung phospholipids consistent with dietary intakes. However, no significant further desaturation/elongation of these dietary precursors was evident. Ovalbumin induced contraction was fully reversed by the lipoxygenase inhibitor esculetin whilst indomethacin resulted in a slight increase possibly due to the inhibition of bronchodilator prostanoids. Results confirm that under the conditions employed airway function was not influenced by the variable dietary intakes of n-3 and n-6 PUFA. | - |
dc.description.statementofresponsibility | M.Y. Abeywardena, L.T. Jablonskis and R.J. Head | - |
dc.language.iso | en | - |
dc.publisher | Churchill Livingstone | - |
dc.rights | © 2001 Harcourt Publishers Ltd | - |
dc.source.uri | http://dx.doi.org/10.1054/plef.2001.0272 | - |
dc.subject | Lung | - |
dc.subject | Bronchi | - |
dc.subject | Animals | - |
dc.subject | Guinea Pigs | - |
dc.subject | Carbachol | - |
dc.subject | Histamine | - |
dc.subject | Umbelliferones | - |
dc.subject | Indomethacin | - |
dc.subject | alpha-Linolenic Acid | - |
dc.subject | Safflower Oil | - |
dc.subject | Fatty Acids | - |
dc.subject | Leukotriene C4 | - |
dc.subject | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid | - |
dc.subject | Dinoprost | - |
dc.subject | Thromboxanes | - |
dc.subject | Linoleic Acid | - |
dc.subject | Fatty Acids, Monounsaturated | - |
dc.subject | Plant Oils | - |
dc.subject | Ovalbumin | - |
dc.subject | Cardiovascular Agents | - |
dc.subject | Vasoconstrictor Agents | - |
dc.subject | Antioxidants | - |
dc.subject | Analysis of Variance | - |
dc.subject | Dose-Response Relationship, Drug | - |
dc.subject | Dietary Supplements | - |
dc.subject | Male | - |
dc.subject | Lipid Metabolism | - |
dc.subject | Olive Oil | - |
dc.subject | Rapeseed Oil | - |
dc.title | Dietary n-3 and n-6 polyunsaturated oils and airway contractility | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1054/plef.2001.0272 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Head, R. [0000-0002-1196-0926] | - |
Appears in Collections: | Aurora harvest 2 Pharmacology publications |
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