Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/14570
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Clinical study of lamotrigine and valproic acid in patients with epilepsy: Using a drug interaction to advantage? |
Author: | Morris, R. Black, A. Lam, E. Westley, I. |
Citation: | Therapeutic Drug Monitoring, 2000; 22(6):656-660 |
Publisher: | Lippincott Williams & Wilkins |
Issue Date: | 2000 |
ISSN: | 0163-4356 1536-3694 |
Statement of Responsibility: | Raymond G. Morris, Andrew B. Black, Esther Lam, and Ian S. Westley |
Abstract: | Lamotrigine (LTG) is one of the newer antiepileptic drugs which has been shown to have a spectrum of drug interactions (including with other epilepsy drugs) that can have a pronounced effect on LTG kinetics. The present study examined the LTG metabolic inhibition dose-response relationship with valproic acid (VPA) in eight patients with epilepsy with a view to using this to benefit the patient. This could benefit the patient not only by attaining higher plasma LTG concentrations with "standard" dosages of LTG, but also possibly by achieving better seizure control through providing a less variable peak-to-trough fluctuation in LTG concentrations as a result of extending the half-life of LTG. The dosages of VPA trialed were 0, 200, 500, and 1,000 mg/d which resulted in a mean increase in LTG area under the curve of 83.7 +/- 14.7% at 200 mg VPA/d, to and 160 +/- 37.9% at 1,000 mg VPA/d. The presence of concomitant enzyme inducers in some patients did not influence the percentage increase from baseline in half-life observed, although clearly those on inducers started from a lower absolute half-life as a result of the induction. The effect was shown to be quite variable, particularly at the highest dosage of VPA tested (1,000 mg/d), suggesting that this effect could be best applied with the support of the therapeutic drug monitoring laboratory determining plasma LTG concentrations to allow individualization of the LTG dosage. |
Keywords: | Humans Epilepsy Valproic Acid Triazines Anticonvulsants Enzyme Inhibitors Drug Therapy, Combination Area Under Curve Dose-Response Relationship, Drug Drug Synergism Half-Life Adult Middle Aged Female Male Lamotrigine |
Rights: | © 2000 Lippincott Williams & Wilkins, Inc. |
DOI: | 10.1097/00007691-200012000-00003 |
Published version: | http://dx.doi.org/10.1097/00007691-200012000-00003 |
Appears in Collections: | Aurora harvest 2 Pharmacology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.