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https://hdl.handle.net/2440/1472
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dc.contributor.author | Ishimaru, J. | - |
dc.contributor.author | Oguma, Y. | - |
dc.contributor.author | Goss, A. | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | British Journal of Oral and Maxillofacial Surgery, 2000; 38(4):354-359 | - |
dc.identifier.issn | 0266-4356 | - |
dc.identifier.issn | 1532-1940 | - |
dc.identifier.uri | http://hdl.handle.net/2440/1472 | - |
dc.description.abstract | We measured matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMP) in temporomandibular joint (TMJ) disorders. All patients were fully investigated, by visual analogue pain scores, plain radiographs and double-contrast arthrotomograms. The patients were grouped according to whether or not they were in pain. There were 35 patients with painful joints; 16 painless crepitating joints and 10 with chronic closed locked joints. A further group of 9 volunteers with no symptoms of TMJ abnormalities were used as controls. We found that synovial fluid concentration of MMP-3 was significantly increased (1117.2 (164.0) ng/ml) (P< 0.05) in the painful group compared with controls (436.2 (94.8) ng/ml) and with the two groups with painless TMJ (475.0 (113. 0) ng/ml/crepitation, and 516.0 (115.1) ng/ml/closed locked joints). MMP-1 and TIMP-1 were not recordable in most joints, and the serum concentrations of MMP-1, MMP-3, and TIMP-1 were similar to those in controls in all groups. There was no correlationship between MMP-3 concentration and joint morphology as shown by plain radiographs and double contrast arthrotomograms. These findings indicate that the synovia of painful joints are inflamed. | - |
dc.language.iso | en | - |
dc.publisher | Churchill Livingstone | - |
dc.source.uri | http://dx.doi.org/10.1054/bjom.2000.0306 | - |
dc.subject | Synovial Fluid | - |
dc.subject | Humans | - |
dc.subject | Temporomandibular Joint Disorders | - |
dc.subject | Synovitis | - |
dc.subject | Facial Pain | - |
dc.subject | Matrix Metalloproteinases | - |
dc.subject | Tissue Inhibitor of Metalloproteinases | - |
dc.subject | Immunoenzyme Techniques | - |
dc.subject | Analysis of Variance | - |
dc.subject | Linear Models | - |
dc.subject | Sensitivity and Specificity | - |
dc.subject | Statistics, Nonparametric | - |
dc.subject | Case-Control Studies | - |
dc.subject | Adolescent | - |
dc.subject | Adult | - |
dc.subject | Aged | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Matrix Metalloproteinase 3 | - |
dc.subject | Matrix Metalloproteinase 1 | - |
dc.title | Matrix metalloproteinase and tissue inhibitor of metalloproteinase in serum and lavage synovial fluid of patients with temporomandibular joint disorders | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1054/bjom.2000.0306 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Goss, A. [0000-0002-2658-3836] | - |
Appears in Collections: | Aurora harvest 6 Dentistry publications |
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