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|Title:||A xylazine infusion regimen to provide analgesia in sheep|
|Citation:||Laboratory Animals, 2001; 35(3):277-281|
|Publisher:||Royal Soc Medicine Press Ltd|
|Abstract:||The efficacy of continuous low-dose xylazine infusion following an initial loading dose in providing analgesia in sheep was examined using an algesimetry method based on a leg lifting response to an electrical stimulus. Sheep received a 5 mg intramuscular injection of xylazine followed by continuous infusion of intravenous xylazine (2 mg/h) for 90 min. This treatment resulted in significant increases in the level of current required to elicit a leg lifting response (287% of baseline) and steady state analgesia was maintained from 10 min after the start of the infusion until the end of the experimental period. This protocol appears to be a simple and effective regimen for providing steady state analgesia in sheep.|
|Keywords:||Animals; Sheep; Xylazine; Adrenergic alpha-Agonists; Analgesia; Injections, Intramuscular; Male|
|Appears in Collections:||Anaesthesia and Intensive Care publications|
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