Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/14758
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zheng, D. | - |
dc.contributor.author | Upton, R. | - |
dc.contributor.author | Martinez, A. | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Xenobiotica: the fate of foreign compounds in biological systems, 2000; 30(11):1079-1090 | - |
dc.identifier.issn | 0049-8254 | - |
dc.identifier.issn | 1366-5928 | - |
dc.identifier.uri | http://hdl.handle.net/2440/14758 | - |
dc.description.abstract | 1. The kinetics of propofol were studied in vivo in a skeletal muscle bed of the hindlimb of the anaesthetized sheep at normal and low rates of blood flow. 2. Propofol kinetics in muscle were determined during and after a 20-min i.v. infusion of propofol (10 mg min-1) via paired arteriofemoral venous blood sampling. One-and-a-half hours later, the study was repeated but with a concurrent left femoral artery infusion of adrenaline (0.004 mg min-1) to lower the muscle blood flow by vasoconstriction. 3. Muscle blood flow in the low flow state was 28% of that in the normal state. The kinetics were poorly described by a single flow-limited compartment model, but were better described by a model with a flow-limited component and a deeper distribution component. There were no significant differences in muscle retention of propofol between normal and low flow states. 4. There was an apparent arteriovenous shunt of approximately 24% of total muscle blood flow for the low flow state, but not for the normal blood flow state. | - |
dc.language.iso | en | - |
dc.publisher | Taylor & Francis Ltd | - |
dc.source.uri | http://dx.doi.org/10.1080/00498250010006582 | - |
dc.subject | Muscles | - |
dc.subject | Muscle, Skeletal | - |
dc.subject | Animals | - |
dc.subject | Sheep | - |
dc.subject | Epinephrine | - |
dc.subject | Propofol | - |
dc.subject | Adrenergic Agonists | - |
dc.subject | Anesthetics, Intravenous | - |
dc.subject | Area Under Curve | - |
dc.subject | Models, Statistical | - |
dc.subject | Oxygen Consumption | - |
dc.subject | Kinetics | - |
dc.subject | Hydrogen-Ion Concentration | - |
dc.subject | Time Factors | - |
dc.subject | Hemodynamics | - |
dc.title | Skeletal muscle kinetics of propofol in anaesthetized sheep: effect of altered muscle blood flow | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1080/00498250010006582 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Upton, R. [0000-0001-9996-4886] | - |
Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest 7 |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.