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Type: Journal article
Title: Ophthalmic manifestations of multiple myeloma
Author: Fung, S.
Selva-Nayagam, D.
Leibovitch, I.
Hsuan, J.
Crompton, J.
Citation: Ophthalmologica, 2005; 219(1):43-48
Publisher: Karger
Issue Date: 2005
ISSN: 0030-3755
Abstract: <h4>Purpose</h4>To describe ophthalmic manifestations in a series of patients with multiple myeloma (MM) and review the literature.<h4>Design</h4>Retrospective case series.<h4>Methods</h4>Review of all cases with ophthalmic manifestations of MM seen at the Department of Ophthalmology, Royal Adelaide Hospital, between 1987 and 2002.<h4>Results</h4>Of all patients with MM who were managed at the Royal Adelaide Hospital in the study period, only 8 were referred to the Ophthalmology Department with ophthalmic manifestations. Five males and 3 females with a mean age of 61.25 years (range 42-78) who exhibited ophthalmic manifestations were studied. Six patients (75%) had known MM at the time of their ophthalmic evaluation. Four patients (50%) had neuro-ophthalmic symptoms resulting in diplopia or visual disturbances. Three patients (37.5%) presented with orbital involvement and 1 (12.5%) with hyperviscosity retinopathy. Five patients (62.5%) died within 2 months of their ophthalmic presentation.<h4>Conclusion</h4>Ophthalmic manifestations of MM are uncommon and diverse. They may appear at the initial presentation of the disease or occur late in the disease process. Awareness of the possible manifestations may lead to an earlier diagnosis and have a positive influence on the disease course.
Keywords: Humans; Multiple Myeloma; Eye Neoplasms; Nervous System Diseases; Vision Disorders; Exophthalmos; Retinal Diseases; Tomography, X-Ray Computed; Magnetic Resonance Imaging; Retrospective Studies; Adult; Aged; Middle Aged; Female; Male
RMID: 0020050027
DOI: 10.1159/000081782
Appears in Collections:Surgery publications

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