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http://hdl.handle.net/2440/16711
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Type: | Journal article |
Title: | Multidisciplinary management of head and neck sarcomas |
Author: | Colville, R. Charlton, F. Kelly, C. Nicoll, J. McLean, N. |
Citation: | Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2005; 27(9):814-824 |
Publisher: | John Wiley & Sons Inc |
Issue Date: | 2005 |
ISSN: | 1043-3074 1097-0347 |
Abstract: | <h4>Background</h4>Head and neck sarcomas are extremely rare. This article reviews the management and outcomes in a multidisciplinary clinic.<h4>Methods</h4>The records of 41 male and 19 female patients (mean age, 50 years) were reviewed. Forty percent underwent surgical resection only, 35% underwent surgery and adjuvant therapy, and 25% underwent radiotherapy and/or chemotherapy without surgery. Seventy-one percent had complete histologic clearance.<h4>Results</h4>The mean follow-up was 3 years and 10 months, with an overall 5-year survival rate of 60%. Completeness of surgical excision was highly significant in determining 5-year local control (p < .025), and the addition of adjuvant radiotherapy had a major effect on local control, but only if complete surgical clearance had been achieved (p < .025). As expected, patients with more aggressive tumors had a significantly poorer overall prognosis, and achieving local control led to an enhanced 5-year survival (p < .025).<h4>Conclusion</h4>These tumors are best managed in multidisciplinary clinics, and the mainstay of treatment is wide local excision and planned postoperative adjuvant radiotherapy. |
Keywords: | Humans; Sarcoma; Head and Neck Neoplasms; Neoplasm Recurrence, Local; Chemotherapy, Adjuvant; Radiotherapy, Adjuvant; Survival Rate; Retrospective Studies; Follow-Up Studies; Adolescent; Adult; Aged; Aged, 80 and over; Middle Aged; Child; Child, Preschool; Infant; Patient Care Team; Female; Male; United Kingdom |
RMID: | 0020052134 |
DOI: | 10.1002/hed.20232 |
Appears in Collections: | Surgery publications |
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