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https://hdl.handle.net/2440/16859
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Type: | Journal article |
Title: | On the virtues of multilateral trade negotiations |
Author: | Anderson, K. |
Citation: | The Economic Record, 2005; 81(255):414-438 |
Publisher: | Blackwell Publishing Asia |
Issue Date: | 2005 |
ISSN: | 0013-0249 1475-4932 |
Abstract: | Allografts used in the repair of congenital heart defects in children induce a persistent broad HLA antibody response. We have previously shown that a 3-month course of mycophenolic mofetil (MMF) significantly reduces the HLA class I antibody response to valved allograft implantation in children. The purpose of this study was to determine if this reduction in HLA antibody persists after discontinuation of MMF. We conducted follow-up (mean 2 +/- 0.5 years) of seven patients who had received allograft placement for repair of congenital heart defects. These patients received 3 months of immunosuppression with MMF following allograft implantation. When compared to historical controls, patients who received MMF following surgery showed a significantly decreased HLA class I antibody response at 2 years postimplantation. This study demonstrates the ability to persistently alter the HLA class I antibody response using 3 months of MMF following allograft implantation in children. |
Keywords: | Heart Valves Humans Heart Defects, Congenital Mycophenolic Acid Immunosuppressive Agents Antibodies Histocompatibility Antigens Class I Histocompatibility Antigens Class II HLA Antigens Fluorescent Antibody Technique, Indirect Histocompatibility Testing Flow Cytometry Sensitivity and Specificity Pilot Projects Immunologic Techniques Antibody Formation Graft Rejection Time Factors Adolescent Child Child, Preschool Infant Infant, Newborn |
Description: | An earlier version was circulated as CEPR Discussion Paper No. 4592, London, September 2004 and as World Bank Policy Research Working Paper 3415, Washington DC, September 2004. |
DOI: | 10.1111/j.1475-4932.2005.00279.x |
Published version: | http://dx.doi.org/10.1111/j.1475-4932.2005.00279.x |
Appears in Collections: | Aurora harvest 2 Economics publications |
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