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|Title:||On the virtues of multilateral trade negotiations|
|Citation:||Economic Record, 2005; 81(255):414-438|
|Publisher:||Blackwell Publishing Asia|
|Abstract:||Allografts used in the repair of congenital heart defects in children induce a persistent broad HLA antibody response. We have previously shown that a 3-month course of mycophenolic mofetil (MMF) significantly reduces the HLA class I antibody response to valved allograft implantation in children. The purpose of this study was to determine if this reduction in HLA antibody persists after discontinuation of MMF. We conducted follow-up (mean 2 +/- 0.5 years) of seven patients who had received allograft placement for repair of congenital heart defects. These patients received 3 months of immunosuppression with MMF following allograft implantation. When compared to historical controls, patients who received MMF following surgery showed a significantly decreased HLA class I antibody response at 2 years postimplantation. This study demonstrates the ability to persistently alter the HLA class I antibody response using 3 months of MMF following allograft implantation in children.|
|Keywords:||Heart Valves; Humans; Heart Defects, Congenital; Mycophenolic Acid; Immunosuppressive Agents; Antibodies; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; HLA Antigens; Fluorescent Antibody Technique, Indirect; Histocompatibility Testing; Flow Cytometry; Sensitivity and Specificity; Pilot Projects; Immunologic Techniques; Antibody Formation; Graft Rejection; Time Factors; Adolescent; Child; Child, Preschool; Infant; Infant, Newborn|
|Description:||An earlier version was circulated as CEPR Discussion Paper No. 4592, London, September 2004 and as World Bank Policy Research Working Paper 3415, Washington DC, September 2004.|
|Appears in Collections:||Economics publications|
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