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Type: Journal article
Title: Lymphoproliferative disease after renal transplantation in Australia and New Zealand
Author: Faull, R.
Hollett, P.
McDonald, S.
Citation: Transplantation, 2005; 80(2):193-197
Publisher: Lippincott Williams & Wilkins
Issue Date: 2005
ISSN: 0041-1337
Abstract: <h4>Background</h4>Lymphoproliferative disease is a common and serious complication of organ transplantation. It is well documented that the risk of its development increases with the level of immunosuppression. Less is known about its incidence, prevalence, timing, and prognosis.<h4>Methods</h4>The authors conducted a retrospective review of all patients with lymphoproliferative disease after renal transplantation documented in the Australia and New Zealand Dialysis and Transplant Registry from 1970 to March 2003.<h4>Results</h4>One hundred ninety-seven cases of lymphoproliferative disease occurred in 15,930 allografts in 13,516 recipients. There has been a steady increase in its incidence and prevalence each decade since 1970. Cases cluster into an early group (<2 years after transplantation) and a late group (5-10 years after transplantation). Risk factors include exposure to a calcineurin inhibitor, but there was no increased risk in those treated with anti-T-lymphocyte antibodies. Patient survival was poor: 51% at 1 year and 39% at 5 years.<h4>Conclusions</h4>Lymphoproliferative disease is an increasingly common problem after renal transplantation, and the outcome is poor. Measures to reduce its incidence might include reduction of long-term immunosuppression exposure. Established disease has a high short-term mortality, and new treatment options, such as anti-B-lymphocyte monoclonal antibodies, should be aggressively pursued.
Keywords: Humans
Herpesvirus 4, Human
Epstein-Barr Virus Infections
Kidney Failure, Chronic
Lymphoproliferative Disorders
Renal Replacement Therapy
Kidney Transplantation
Proportional Hazards Models
Retrospective Studies
Middle Aged
Child, Preschool
New Zealand
DOI: 10.1097/01.TP.0000165098.49658.F3
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