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Type: Journal article
Title: Both estrogen and progesterone attenuate edema formation following diffuse traumatic brain injury in rats
Author: O'Connor, C.
Cernak, I.
Vink, R.
Citation: Brain Research, 2005; 1062(1-2):171-174
Publisher: Elsevier Science Bv
Issue Date: 2005
ISSN: 0006-8993
Statement of
Christine A. O'Connora, Ibolja Cernakc and Robert Vink
Abstract: Females have reduced brain edema compared to males after experimental brain trauma, although contradictory reports exist as to whether this is due to either estrogen or progesterone. In the present study, we demonstrate in both male and ovariectomized female rats that a single physiological dose of either hormone at 30 min after diffuse traumatic brain injury reduces both blood brain barrier permeability and edema formation. We conclude that both hormones may contribute to reduce edema in females after brain injury.
Keywords: neurotrauma
blood brain barrier
brain injury
Description: Available online 26 October 2005.
Rights: Copyright © 2005 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.brainres.2005.09.011
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Appears in Collections:Aurora harvest 6
Pathology publications

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