Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/22879
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBowen, J.-
dc.contributor.authorNoakes, M.-
dc.contributor.authorClifton, P.-
dc.date.issued2006-
dc.identifier.citationJournal of Clinical Endocrinology and Metabolism, 2006; 91(8):2913-2919-
dc.identifier.issn0021-972X-
dc.identifier.issn0021-972X-
dc.identifier.urihttp://hdl.handle.net/2440/22879-
dc.description.abstract<h4>Context</h4>Although dietary protein produces higher acute satiety relative to carbohydrate, the influence of protein source and body mass index (BMI) has not been clearly described.<h4>Objective</h4>The objective of the study was to assess postprandial responses to different protein sources, compared with glucose, in males with normal and high BMI.<h4>Design</h4>This was a randomized, crossover study of four preloads followed by blood sampling (+15, 30, 45, 60, 90, 120, 180 min) and buffet meal.<h4>Setting</h4>The study was conducted at an outpatient clinic.<h4>Participants</h4>The study population included 72 men, with a BMI range 20.6-39.9 kg/m(2).<h4>Interventions</h4>Interventions consisted of liquid preloads (1.1 MJ, 450 ml) containing 50 g whey, soy, gluten, or glucose.<h4>Main outcome measures</h4>Fasting and postprandial plasma glucose, insulin, ghrelin, glucagon-like peptide-1 (GLP-1) and cholecystokinin (n = 38), ad libitum energy intake, and appetite ratings were measured.<h4>Results</h4>Energy intake was 10% lower after all protein preloads, compared with the glucose treatment (P < 0.05), independent of BMI status and protein type. All protein loads prolonged the postprandial suppression of ghrelin (P < 0.01) and elevation of GLP-1 (P < 0.01) and cholecystokinin (P < 0.05). Fasting GLP-1 concentrations [overweight, 17.5 +/- 1.3; lean, 14.7 +/- 0.1 pg/ml (5.2 +/- 0.4 and 4.4 +/- 0.1 pmol/liter, respectively); P < 0.001] and postprandial responses (P = 0.038) were higher in overweight subjects.<h4>Conclusions</h4>Whey, soy, and gluten similarly tend to reduce ad libitum food intake 3 h later in lean and overweight males relative to glucose. Postprandial ghrelin, GLP-1, insulin, and cholecystokinin may contribute to this higher satiety after protein consumption. GLP-1 concentrations are increased in overweight subjects, which may affect satiety responses in this group.-
dc.description.statementofresponsibilityBowen, Jane; Noakes, Manny; Clifton, Peter M-
dc.language.isoen-
dc.publisherEndocrine Society-
dc.subjectHumans-
dc.subjectObesity-
dc.subjectBody Weight-
dc.subjectHormones-
dc.subjectCholecystokinin-
dc.subjectInsulin-
dc.subjectPeptide Hormones-
dc.subjectBlood Glucose-
dc.subjectDietary Proteins-
dc.subjectMilk Proteins-
dc.subjectSoybean Proteins-
dc.subjectBody Mass Index-
dc.subjectRegression Analysis-
dc.subjectCross-Over Studies-
dc.subjectSatiation-
dc.subjectEnergy Intake-
dc.subjectAppetite Regulation-
dc.subjectEating-
dc.subjectKinetics-
dc.subjectAdult-
dc.subjectAged-
dc.subjectMiddle Aged-
dc.subjectMale-
dc.subjectGlucagon-Like Peptide 1-
dc.subjectGhrelin-
dc.subjectGlutens-
dc.subjectWhey Proteins-
dc.titleAppetite regulatory hormone responses to various dietary proteins differ by body mass index status despite similar reductions in ad libitum energy intake-
dc.typeJournal article-
dc.identifier.doi10.1210/jc.2006-0609-
pubs.publication-statusPublished-
dc.identifier.orcidClifton, P. [0000-0002-6411-626X]-
Appears in Collections:Aurora harvest 2
Surgery publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.