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https://hdl.handle.net/2440/22879
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dc.contributor.author | Bowen, J. | - |
dc.contributor.author | Noakes, M. | - |
dc.contributor.author | Clifton, P. | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Journal of Clinical Endocrinology and Metabolism, 2006; 91(8):2913-2919 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.uri | http://hdl.handle.net/2440/22879 | - |
dc.description.abstract | <h4>Context</h4>Although dietary protein produces higher acute satiety relative to carbohydrate, the influence of protein source and body mass index (BMI) has not been clearly described.<h4>Objective</h4>The objective of the study was to assess postprandial responses to different protein sources, compared with glucose, in males with normal and high BMI.<h4>Design</h4>This was a randomized, crossover study of four preloads followed by blood sampling (+15, 30, 45, 60, 90, 120, 180 min) and buffet meal.<h4>Setting</h4>The study was conducted at an outpatient clinic.<h4>Participants</h4>The study population included 72 men, with a BMI range 20.6-39.9 kg/m(2).<h4>Interventions</h4>Interventions consisted of liquid preloads (1.1 MJ, 450 ml) containing 50 g whey, soy, gluten, or glucose.<h4>Main outcome measures</h4>Fasting and postprandial plasma glucose, insulin, ghrelin, glucagon-like peptide-1 (GLP-1) and cholecystokinin (n = 38), ad libitum energy intake, and appetite ratings were measured.<h4>Results</h4>Energy intake was 10% lower after all protein preloads, compared with the glucose treatment (P < 0.05), independent of BMI status and protein type. All protein loads prolonged the postprandial suppression of ghrelin (P < 0.01) and elevation of GLP-1 (P < 0.01) and cholecystokinin (P < 0.05). Fasting GLP-1 concentrations [overweight, 17.5 +/- 1.3; lean, 14.7 +/- 0.1 pg/ml (5.2 +/- 0.4 and 4.4 +/- 0.1 pmol/liter, respectively); P < 0.001] and postprandial responses (P = 0.038) were higher in overweight subjects.<h4>Conclusions</h4>Whey, soy, and gluten similarly tend to reduce ad libitum food intake 3 h later in lean and overweight males relative to glucose. Postprandial ghrelin, GLP-1, insulin, and cholecystokinin may contribute to this higher satiety after protein consumption. GLP-1 concentrations are increased in overweight subjects, which may affect satiety responses in this group. | - |
dc.description.statementofresponsibility | Bowen, Jane; Noakes, Manny; Clifton, Peter M | - |
dc.language.iso | en | - |
dc.publisher | Endocrine Society | - |
dc.source.uri | http://dx.doi.org/10.1210/jc.2006-0609 | - |
dc.subject | Humans | - |
dc.subject | Obesity | - |
dc.subject | Body Weight | - |
dc.subject | Hormones | - |
dc.subject | Cholecystokinin | - |
dc.subject | Insulin | - |
dc.subject | Peptide Hormones | - |
dc.subject | Blood Glucose | - |
dc.subject | Dietary Proteins | - |
dc.subject | Milk Proteins | - |
dc.subject | Soybean Proteins | - |
dc.subject | Body Mass Index | - |
dc.subject | Regression Analysis | - |
dc.subject | Cross-Over Studies | - |
dc.subject | Satiation | - |
dc.subject | Energy Intake | - |
dc.subject | Appetite Regulation | - |
dc.subject | Eating | - |
dc.subject | Kinetics | - |
dc.subject | Adult | - |
dc.subject | Aged | - |
dc.subject | Middle Aged | - |
dc.subject | Male | - |
dc.subject | Glucagon-Like Peptide 1 | - |
dc.subject | Ghrelin | - |
dc.subject | Glutens | - |
dc.subject | Whey Proteins | - |
dc.title | Appetite regulatory hormone responses to various dietary proteins differ by body mass index status despite similar reductions in ad libitum energy intake | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1210/jc.2006-0609 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Clifton, P. [0000-0002-6411-626X] | - |
Appears in Collections: | Aurora harvest 2 Surgery publications |
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