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https://hdl.handle.net/2440/23998
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dc.contributor.author | Pinkett, H. | - |
dc.contributor.author | Shearwin, K. | - |
dc.contributor.author | Stayrook, S. | - |
dc.contributor.author | Dodd, I. | - |
dc.contributor.author | Burr, T. | - |
dc.contributor.author | Hochschild, A. | - |
dc.contributor.author | Egan, J. | - |
dc.contributor.author | Lewis, M. | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Molecular Cell, 2006; 21(5):605-615 | - |
dc.identifier.issn | 1097-4164 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.uri | http://hdl.handle.net/2440/23998 | - |
dc.description.abstract | Bacteriophage λ is a paradigm for understanding the role of cooperativity in gene regulation. Comparison of the regulatory regions of λ and the unrelated temperate bacteriophage 186 provides insight into alternate ways to assemble functional genetic switches. The structure of the C-terminal domain of the 186 repressor, determined at 2.7 Å resolution, reveals an unusual heptamer of dimers, consistent with presented genetic studies. In addition, the structure of a cooperativity mutant of the full-length 186 repressor, identified by genetic screens, was solved to 1.95 Å resolution. These structures provide a molecular basis for understanding lysogenic regulation in 186. Whereas the overall fold of the 186 and λ repressor monomers is remarkably similar, the way the two repressors cooperatively assemble is quite different and explains in part the differences in their regulatory activity. | - |
dc.description.statementofresponsibility | Heather W. Pinkett, Keith E. Shearwin, Steven Stayrook, Ian B. Dodd, Tom Burr, Ann Hochschild, J. Barry Egan and Mitchell Lewis | - |
dc.description.uri | http://www.molecule.org/ | - |
dc.language.iso | en | - |
dc.publisher | Cell Press | - |
dc.rights | Copyright © 2007 Elsevier | - |
dc.source.uri | http://dx.doi.org/10.1016/j.molcel.2006.01.019 | - |
dc.subject | Bacteriophage lambda | - |
dc.subject | Coliphages | - |
dc.subject | Repressor Proteins | - |
dc.subject | Viral Proteins | - |
dc.subject | DNA, Viral | - |
dc.subject | Crystallography, X-Ray | - |
dc.subject | Amino Acid Substitution | - |
dc.subject | Virus Assembly | - |
dc.subject | Gene Expression Regulation, Viral | - |
dc.subject | Protein Structure, Tertiary | - |
dc.subject | Structure-Activity Relationship | - |
dc.subject | Dimerization | - |
dc.title | The structural basis of cooperative regulation at an alternate genetic switch | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.molcel.2006.01.019 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Shearwin, K. [0000-0002-7736-2742] | - |
dc.identifier.orcid | Dodd, I. [0000-0003-2969-6841] | - |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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