Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/24079
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Type: Journal article
Title: Active surveillance for candidemia, Australia
Author: Chen, S.
Slavin, M.
Nguyen, Q.
Marriott, D.
Playford, E.
Ellis, D.
Sorrell, T.
Citation: Emerging Infectious Diseases, 2006; 12(10):1508-1516
Publisher: Center Disease Control
Issue Date: 2006
ISSN: 1080-6040
1080-6059
Abstract: Population-based surveillance for candidemia in Australia from 2001 to 2004 identified 1,095 cases. Annual overall and hospital-specific incidences were 1.81/100,000 and 0.21/1,000 separations (completed admissions), respectively. Predisposing factors included malignancy (32.1%), indwelling vascular catheters (72.6%), use of antimicrobial agents (77%), and surgery (37.1%). Of 919 episodes, 81.5% were inpatient healthcare associated (IHCA), 11.6% were outpatient healthcare associated (OHCA), and 6.9% were community acquired (CA). Concomitant illnesses and risk factors were similar in IHCA and OHCA candidemia. IHCA candidemia was associated with sepsis at diagnosis (p<0.001), death <30 days after infection (p<0.001), and prolonged hospital admission (p<0.001). Non-Candida albicans species (52.7%) caused 60.5% of cases acquired outside hospitals and 49.9% of IHCA candidemia (p = 0.02). The 30-day death rate was 27.7% in those > or =65 years of age. Adult critical care stay, sepsis syndrome, and corticosteroid therapy were associated with the greatest risk for death. Systematic epidemiologic studies that use standardized definitions for IHCA, OHCA, and CA candidemia are indicated.
Keywords: Australian Candidemia Study; Humans; Cross Infection; Fungemia; Candidiasis; Incidence; Risk Factors; Retrospective Studies; Adolescent; Adult; Aged; Middle Aged; Child; Child, Preschool; Infant; Infant, Newborn; Australia
RMID: 0020061408
DOI: 10.3201/eid1210.060389
Appears in Collections:Molecular and Biomedical Science publications

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