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Type: Journal article
Title: Early treatment of the pregnant guinea pig with IGFs promotes placental transport and nutrient partitioning near term
Author: Sferruzzi-Perri, A.
Owens, J.
Standen, P.
Taylor, R.
Heinemann, G.
Robinson, J.
Roberts, C.
Citation: American Journal of Physiology-Endocrinology and Metabolism, 2007; 292(3):E668-E676
Publisher: Amer Physiological Soc
Issue Date: 2007
ISSN: 0193-1849
Statement of
Amanda N. Sferruzzi-Perri, Julie A. Owens, Prue Standen, Robyn L. Taylor, Gary K. Heinemann, Jeffrey S. Robinson, and Claire T. Roberts
Abstract: Appropriate partitioning of nutrients between the mother and conceptus is a major determinant of pregnancy success, with placental transfer playing a key role. Insulin-like growth factors (IGFs) increase in the maternal circulation during early pregnancy and are predictive of fetal and placental growth. We have previously shown in the guinea pig that increasing maternal IGF abundance in early to midpregnancy enhances fetal growth and viability near term. We now show that this treatment promotes placental transport to the fetus, fetal substrate utilization, and nutrient partitioning near term. Pregnant guinea pigs were infused with IGF-I, IGF-II (both 1 mg·kg–1·day–1) or vehicle subcutaneously from days 20–38 of pregnancy (term = 69 days). Tissue uptake and placental transfer of the nonmetabolizable radio analogs [3H]methyl-D-glucose (MG) and [14C]aminoisobutyric acid (AIB) in vivo was measured on day 62. Early pregnancy exposure to elevated maternal IGF-I increased placental MG uptake by >70% (P = 0.004), whereas each IGF increased fetal plasma MG concentrations by 40–50% (P < 0.012). Both IGFs increased fetal tissue MG uptake (P < 0.048), whereas IGF-I also increased AIB uptake by visceral organs (P = 0.046). In the mother, earlier exposure to either IGF increased AIB uptake by visceral organs (P < 0.014), whereas IGF-I also enhanced uptake of AIB by muscle (P = 0.044) and MG uptake by visceral organs (P = 0.016) and muscle (P = 0.046). In conclusion, exogenous maternal IGFs in early pregnancy sustainedly increase maternal substrate utilization, placental transport of MG to the fetus, and fetal utilization of substrates near term. This was consistent with the previously observed increase in fetal growth and survival following IGF treatment.
Keywords: Heart; Placenta; Animals; Guinea Pigs; Fetal Weight; Aminoisobutyric Acids; Methylglucosides; Somatomedins; Biological Transport; Gestational Age; Pregnancy; Maternal-Fetal Exchange; Term Birth; Pregnancy, Animal; Litter Size; Food; Female
Description: Copyright © 2007 by the American Physiological Society
RMID: 0020070308
DOI: 10.1152/ajpendo.00320.2006
Published version:
Appears in Collections:Molecular and Biomedical Science publications

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