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Type: Journal article
Title: Transcriptional control of pluripotency: decisions in early development
Author: Johnson, B.
Rathjen, J.
Rathjen, P.
Citation: Current Opinion in Genetics & Development, 2006; 16(5):447-454
Publisher: Current Biology Ltd
Issue Date: 2006
ISSN: 0959-437X
Organisation: Centre for the Molecular Genetics of Development
Statement of
Brett Vaughan Johnson, Joy Rathjen and Peter David Rathjen
Abstract: The pathways controlling the maintenance and loss of pluripotency in cells of the early embryo regulate the formation of the tissues that will support development. Several transcription factors have been identified as being integral to the establishment and/or maintenance of pluripotency, coordinately regulating the expression of genes within pluripotent cells and acting as gene targets of these same processes. Recent advances in understanding the transcriptional regulation of these factors have revealed differences in the transcriptional complexes present within sub-populations of the pluripotent lineage and in the mechanisms regulating the loss of pluripotency on differentiation.
Keywords: Pluripotent Stem Cells; Animals; Humans; Transcription Factors; Transcription, Genetic; Gene Expression Regulation, Developmental; Cell Lineage; Time Factors
RMID: 0020061558
DOI: 10.1016/j.gde.2006.08.012
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Appears in Collections:Molecular and Biomedical Science publications
Centre for the Molecular Genetics of Development publications

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