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Type: Journal article
Title: Impact of periconceptional nutrition on maternal and fetal leptin and fetal adiposity in singleton and twin pregnancies
Author: Edwards, L.
McFarlane, J.
Kauter, K.
McMillen, I.
Citation: American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 2005; 288(1):R39-R45
Publisher: Amer Physiological Soc
Issue Date: 2005
ISSN: 0363-6119
Abstract: It has been proposed that maternal nutrient restriction may alter the functional development of the adipocyte and the synthesis and secretion of the adipocyte-derived hormone, leptin, before birth. We have investigated the effects of restricted periconceptional undernutrition and/or restricted gestational nutrition on fetal plasma leptin concentrations and fetal adiposity in late gestation. There was no effect of either restricted periconceptional or gestational nutrition on maternal or fetal plasma leptin concentrations in singleton or twin pregnancies during late gestation. In ewes carrying twins, but not singletons, maternal plasma leptin concentrations in late gestation were directly related to the change in ewe weight that occurred during the 60 days before mating [maternal leptin = 0.9 (change in ewe weight) + 7.8; r = 0.6, P < 0.05]. In twin, but not singleton, pregnancies, there was also a significant relationship between maternal and fetal leptin concentrations (maternal leptin = 0.5 fetal leptin + 4.2, r = 0.63, P < 0.005). The relative mass of perirenal fat was also significantly increased in twin fetal sheep in the control-restricted group (6.0 +/- 0.5) compared with the other nutritional groups (control-control: 4.1 +/- 0.4; restricted-restricted: 4.4 +/- 0.4; restricted-control: 4.3 +/- 0.3). In conclusion, the impact of maternal undernutrition on maternal plasma leptin concentrations during late gestation is dependent on fetal number. Furthermore, we have found that there is an increased fetal adiposity in the twins of ewes that experienced restricted nutrition throughout gestation, and this may be important in the programming of postnatal adiposity.
Keywords: Kidney; Adipose Tissue; Fetus; Animals; Sheep; Body Weight; Fetal Weight; Leptin; Blood Glucose; Fetal Development; Pregnancy; Twins; Female; Prenatal Nutritional Physiological Phenomena
RMID: 0020050023
DOI: 10.1152/ajpregu.00127.2004
Appears in Collections:Molecular and Biomedical Science publications

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