Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/27545
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Type: Journal article
Title: Molecular interactions of the IGF system
Author: Denley, A.
Cosgrove, L.
Booker, G.
Wallace, J.
Forbes, B.
Citation: Cytokine and Growth Factor Reviews, 2005; 16(4-5):421-439
Publisher: Elsevier Sci Ltd
Issue Date: 2005
ISSN: 1359-6101
1879-0305
Statement of
Responsibility: 
Adam Denley, Leah J. Cosgrove, Grant W. Booker, John C. Wallace, and Briony E. Forbes
Abstract: The insulin-like growth factor (IGF) system is a complex network of two soluble ligands; several cell surface transmembrane receptors and six soluble high-affinity binding-proteins. The IGF system is essential for normal embryonic and postnatal growth, and plays an important role in the function of a healthy immune system, lymphopoiesis, myogenesis and bone growth among other physiological functions. Deregulation of the IGF system leads to stimulation of cancer cell growth and survival. In order to manipulate the IGF system in the treatment of certain disorders, we must understand the protein–protein interactions at a molecular level. The complex molecular interactions of the ligands and receptors of the IGF system underlie all the biological actions mentioned above and will be the focus of this review.
Keywords: Insulin-like growth factor
IGF receptors
IGFBP
Structure
Function
Description: Copyright © 2007 Elsevier B.V.
DOI: 10.1016/j.cytogfr.2005.04.004
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/868/description#description
Published version: http://dx.doi.org/10.1016/j.cytogfr.2005.04.004
Appears in Collections:Aurora harvest 2
Molecular and Biomedical Science publications

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