Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/28039
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Type: Journal article
Title: In vitro pharmacodynamic properties of colistin and colistin methanesulfonate against Pseudomonas aeruginosa isolates from patients with cystic fibrosis
Author: Li, J.
Turnidge, J.
Milne, R.
Nation, R.
Coulthard, K.
Citation: Antimicrobial Agents and Chemotherapy, 2001; 45(3):781-785
Publisher: Amer Soc Microbiology
Issue Date: 2001
ISSN: 0066-4804
1098-6596
Abstract: The in vitro pharmacodynamic properties of colistin and colistin methanesulfonate were investigated by studying the MICs, time-kill kinetics, and postantibiotic effect (PAE) against mucoid and nonmucoid strains of Pseudomonas aeruginosa isolated from patients with cystic fibrosis. Twenty-three clinical strains, including multiresistant strains, and one type strain were selected for MIC determination. Eleven strains were resistant; MICs for these strains were >128 mg/liter. For the susceptible strains, MICs of colistin ranged from 1 to 4 mg/liter, while the MICs of colistin methanesulfonate were significantly higher and ranged from 4 to 16 mg/liter. The time-kill kinetics were investigated with three strains at drug concentrations ranging from 0.5 to 64 times the MIC. Colistin showed extremely rapid killing, resulting in complete elimination at the highest concentrations within 5 min, while colistin methanesulfonate killed more slowly, requiring a concentration of 16 times the MIC to achieve complete killing within 24 h. Colistin exhibited a significant PAE of 2 to 3 h at 16 times the MIC against the three strains after 15 min of exposure. For colistin methanesulfonate, PAEs were shorter at the concentrations tested. Colistin methanesulfonate had lower overall bactericidal and postantibiotic activities than colistin, even when adjusted for differences in MICs. Our data suggest that doses of colistin methanesulfonate higher than the recommended 2 to 3 mg/kg of body weight every 12 h may be required for the effective treatment of P. aeruginosa infections in cystic fibrosis patients.
Keywords: Humans
Pseudomonas aeruginosa
Pseudomonas Infections
Cystic Fibrosis
Colistin
Anti-Bacterial Agents
Microbial Sensitivity Tests
Kinetics
Time Factors
DOI: 10.1128/AAC.45.3.781-785.2001
Appears in Collections:Aurora harvest 6
Molecular and Biomedical Science publications

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