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https://hdl.handle.net/2440/28127
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dc.contributor.author | Andersson, P. | - |
dc.contributor.author | McGuire, J. | - |
dc.contributor.author | Rubio, C. | - |
dc.contributor.author | Gradin, K. | - |
dc.contributor.author | Whitelaw, M. | - |
dc.contributor.author | Pettersson, S. | - |
dc.contributor.author | Hanberg, A. | - |
dc.contributor.author | Poellinger, L. | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of USA, 2002; 99(15):9990-9995 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.issn | 1091-6490 | - |
dc.identifier.uri | http://hdl.handle.net/2440/28127 | - |
dc.description | Published online before print July 9, 2002 | - |
dc.description.abstract | The dioxin/aryl hydrocarbon receptor (AhR) functions as a ligand-activated transcription factor regulating transcription of a battery of genes encoding xenobiotic metabolizing enzymes. Known receptor ligands are environmental pollutants including polycyclic aromatic hydrocarbons and polychlorinated dioxins. Loss-of-function (gene-disruption) studies in mice have demonstrated that the AhR is involved in toxic effects of dioxins but have not yielded unequivocal results concerning the physiological function of the receptor. Gain-of-function studies therefore were performed to unravel the biological functions of the AhR. A constitutively active AhR expressed in transgenic mice reduced the life span of the mice and induced tumors in the glandular part of the stomach, demonstrating the oncogenic potential of the AhR and implicating the receptor in regulation of cell proliferation. | - |
dc.description.statementofresponsibility | Patrik Andersson, Jacqueline McGuire, Carlos Rubio, Katarina Gradin, Murray L. Whitelaw, Sven Pettersson, Annika Hanberg, and Lorenz Poellinger | - |
dc.language.iso | en | - |
dc.publisher | Natl Acad Sciences | - |
dc.rights | Copyright © 2002 by the National Academy of Sciences | - |
dc.source.uri | http://www.pnas.org/content/99/15/9990 | - |
dc.subject | Liver | - |
dc.subject | Thymus Gland | - |
dc.subject | CHO Cells | - |
dc.subject | Animals | - |
dc.subject | Mice, Inbred C57BL | - |
dc.subject | Mice, Inbred CBA | - |
dc.subject | Mice | - |
dc.subject | Intestinal Neoplasms | - |
dc.subject | Stomach Neoplasms | - |
dc.subject | Cytochrome P-450 CYP1A1 | - |
dc.subject | Receptors, Aryl Hydrocarbon | - |
dc.subject | Recombinant Proteins | - |
dc.subject | Carcinogens | - |
dc.subject | Cloning, Molecular | - |
dc.subject | Transfection | - |
dc.subject | Gene Expression Regulation, Developmental | - |
dc.subject | Cricetinae | - |
dc.subject | Male | - |
dc.subject | Polychlorinated Dibenzodioxins | - |
dc.title | A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors | - |
dc.type | Journal article | - |
dc.contributor.organisation | Centre for the Molecular Genetics of Development | - |
dc.identifier.doi | 10.1073/pnas.152706299 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 2 Centre for the Molecular Genetics of Development publications Molecular and Biomedical Science publications |
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