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https://hdl.handle.net/2440/2997
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Type: | Journal article |
Title: | Binding site for the C-domain of insulin-like growth factor (IGF) binding protein-6 on IGF-II; implications for inhibition of IGF actions |
Author: | Headey, S. Keizer, D. Yao, S. Wallace, J. Bach, L. Norton, R. |
Citation: | FEBS Letters, 2004; 568(1-3):19-22 |
Publisher: | Elsevier Science BV |
Issue Date: | 2004 |
ISSN: | 0014-5793 1873-3468 |
Statement of Responsibility: | Stephen J. Headey, David W. Keizer, Shenggen Yao, John C. Wallace, Leon A. Bach, and Raymond S. Norton |
Abstract: | Insulin-like growth factors (IGFs) are important mediators of growth and IGF-binding proteins (IGFBPs) 1–6 regulate IGF actions. As IGFBP C-terminal domains contribute to high-affinity IGF binding, we have defined the binding site for the C-domain of IGFBP-6 on IGF-II using NMR. This site lies adjacent to and between the binding sites for the IGFBP N-domain and IGF-I receptor (IGFIR), which have previously been found on opposite sides of the IGF molecule. The C-domain is therefore likely to interfere with IGF binding to the IGFIR, providing a structural basis for the potent inhibitory effects of intact IGFBPs on IGF actions. |
Keywords: | Insulin-like growth factor Binding protein Structure Nuclear magnetic resonance Interaction surface |
Description: | Copyright © 2004 Federation of European Biochemical Societies |
DOI: | 10.1016/j.febslet.2004.04.091 |
Published version: | http://dx.doi.org/10.1016/j.febslet.2004.04.091 |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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