Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/3005
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Molecular characterization and analysis of the acrB gene of Aspergillus nidulans: A gene identified by genetic interaction as a component of the regulatory network that includes the CreB deubiquitination enzyme |
Author: | Boase, N. Lockington, R. Adams, J. Rodbourn, L. Kelly, J. |
Citation: | Genetics: a periodical record of investigations bearing on heredity and variation, 2003; 164(1):95-104 |
Publisher: | Genetics |
Issue Date: | 2003 |
ISSN: | 0016-6731 1943-2631 |
Statement of Responsibility: | Natasha A. Boase, Robin A. Lockington, Julian R. J. Adams, Louise Rodbourn and Joan M. Kelly |
Abstract: | Mutations in the acrB gene, which were originally selected through their resistance to acriflavine, also result in reduced growth on a range of sole carbon sources, including fructose, cellobiose, raffinose, and starch, and reduced utilization of ω-amino acids, including GABA and ß-alanine, as sole carbon and nitrogen sources. The acrB2 mutation suppresses the phenotypic effects of mutations in the creB gene that encodes a regulatory deubiquitinating enzyme, and in the creC gene that encodes a WD40-repeat-containing protein. Thus AcrB interacts with a regulatory network controlling carbon source utilization that involves ubiquitination and deubiquitination. The acrB gene was cloned and physically analyzed, and it encodes a novel protein that contains three putative transmembrane domains and a coiled-coil region. AcrB may play a role in the ubiquitination aspect of this regulatory network. |
Keywords: | Aspergillus nidulans Acriflavine Amino Acid Sequence Base Sequence Mutation Molecular Sequence Data |
Description: | Copyright © 2003 by the Genetics Society of America |
DOI: | 10.1093/genetics/164.1.95 |
Published version: | http://www.genetics.org/cgi/content/abstract/164/1/95 |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Boa_Mol_v164n12002.pdf | 286.35 kB | Publisher's PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.