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Type: Journal article
Title: Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function
Author: Darnell, J.
Jensen, K.
Jin, P.
Brown, V.
Warren, S.
Darnell, R.
Citation: Cell, 2001; 107(4):489-499
Publisher: Cell Press
Issue Date: 2001
ISSN: 0092-8674
Statement of
Jennifer C. Darnell, Kirk B. Jensen, Peng Jin, Victoria Brown, Stephen T. Warren and Robert B. Darnell
Abstract: Loss of fragile X mental retardation protein (FMRP) function causes the fragile X mental retardation syndrome. FMRP harbors three RNA binding domains, associates with polysomes, and is thought to regulate mRNA translation and/or localization, but the RNAs to which it binds are unknown. We have used RNA selection to demonstrate that the FMRP RGG box binds intramolecular G quartets. This data allowed us to identify mRNAs encoding proteins involved in synaptic or developmental neurobiology that harbor FMRP binding elements. The majority of these mRNAs have an altered polysome association in fragile X patient cells. These data demonstrate that G quartets serve as physiologically relevant targets for FMRP and identify mRNAs whose dysregulation may underlie human mental retardation.
Keywords: Neurons
Fragile X Syndrome
RNA-Binding Proteins
Nerve Tissue Proteins
DNA, Complementary
RNA, Messenger
Sequence Alignment
Protein Biosynthesis
Binding Sites
Base Sequence
Regulatory Sequences, Nucleic Acid
Consensus Sequence
Nucleic Acid Conformation
Protein Structure, Tertiary
Protein Binding
Genetic Vectors
Molecular Sequence Data
Fragile X Mental Retardation Protein
DOI: 10.1016/S0092-8674(01)00566-9
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Appears in Collections:Aurora harvest
Molecular and Biomedical Science publications

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