Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Segmental duplication associated with evolutionary instability of human chromosome 3p25
Author: Yue, Y.
Tsend-Ayush, E.
Grutzner, F.
Grossmann, B.
Haaf, T.
Citation: Cytogenetic and Genome Research, 2006; 112(3-4):202-207
Publisher: Karger
Issue Date: 2006
ISSN: 1424-8581
Statement of
Y. Yue; E. Tsend-Ayush; F. Grützner; B. Grossmann and T. Haaf
Abstract: Fluorescence in situ hybridization (FISH) of human bacterial artificial chromosome (BAC) clones to orangutan metaphase spreads localized a breakpoint between human chromosome 3p25.1 and orangutan chromosome 2 to a <30-kb interval. The inversion occurred in a relatively gene-rich region with seven genes within 500 kb. The underlying breakpoint is closely juxtaposed to validated genes, however no functional gene has been disrupted by the evolutionary rearrangement. An approximately 21-kb DNA segment at the 3p25.1 breakpoint region has been duplicated intrachromosomally and interchromosomally to multiple regions in the orangutan and human genomes, providing additional evidence for the role of segmental duplications in hominoid chromosome evolution.
Keywords: Chromosomes, Human, Pair 3
Gorilla gorilla
Chromosomal Instability
In Situ Hybridization, Fluorescence
Chromosome Mapping
Evolution, Molecular
Gene Duplication
DOI: 10.1159/000089871
Appears in Collections:Aurora harvest 6
Environment Institute Leaders publications
Molecular and Biomedical Science publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.