Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/34798
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Type: Journal article
Title: Segmental duplication associated with evolutionary instability of human chromosome 3p25
Author: Yue, Y.
Tsend-Ayush, E.
Grutzner, F.
Grossmann, B.
Haaf, T.
Citation: Cytogenetic and Genome Research, 2006; 112(3-4):202-207
Publisher: Karger
Issue Date: 2006
ISSN: 1424-8581
1424-859X
Statement of
Responsibility: 
Y. Yue; E. Tsend-Ayush; F. Grützner; B. Grossmann and T. Haaf
Abstract: Fluorescence in situ hybridization (FISH) of human bacterial artificial chromosome (BAC) clones to orangutan metaphase spreads localized a breakpoint between human chromosome 3p25.1 and orangutan chromosome 2 to a <30-kb interval. The inversion occurred in a relatively gene-rich region with seven genes within 500 kb. The underlying breakpoint is closely juxtaposed to validated genes, however no functional gene has been disrupted by the evolutionary rearrangement. An approximately 21-kb DNA segment at the 3p25.1 breakpoint region has been duplicated intrachromosomally and interchromosomally to multiple regions in the orangutan and human genomes, providing additional evidence for the role of segmental duplications in hominoid chromosome evolution.
Keywords: Chromosomes, Human, Pair 3; Animals; Gorilla gorilla; Humans; Yeasts; Chromosomal Instability; In Situ Hybridization, Fluorescence; Chromosome Mapping; Karyotyping; Evolution, Molecular; Phylogeny; Gene Duplication
RMID: 0020063768
DOI: 10.1159/000089871
Appears in Collections:Molecular and Biomedical Science publications
Environment Institute Leaders publications

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