Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/35525
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | CXCL16 regulates cell-mediated immunity to Salmonella enterica serovar Enteritidis via promotion of gamma interferon production |
Author: | Fahy, O. Townley, S. McColl, S. |
Citation: | Infection and Immunity, 2006; 74(12):6885-6894 |
Publisher: | Amer Soc Microbiology |
Issue Date: | 2006 |
ISSN: | 0019-9567 1098-5522 |
Statement of Responsibility: | Olivier L. Fahy, Scott L. Townley, and Shaun R. McColl |
Abstract: | CXCL16 is a recently discovered multifaceted chemokine that has been shown not only to recruit activated T lymphocytes but also to play a direct role in the binding and phagocytosis of bacteria by professional antigen-presenting cells. In this study, we investigated the role of CXCL16 in vivo in the regulation of the immune response using a murine model of Salmonella enterica serovar Enteritidis infection. The expression of CXCL16 was strongly upregulated in the spleens and livers of animals developing an immune response to a primary acute infection but not in the Peyer's patches. Animals developing a secondary response after reexposure to the bacteria displayed a similar pattern of expression. During the primary response, prior treatment with neutralizing antibodies to CXCL16 induced a significant increase in bacterial burden in the spleen and liver. The production of gamma interferon (IFN-γ) by the lymphocytes in the spleen was decreased by anti-CXCL16 treatment. In comparison, during the secondary response, anti-CXCL16 treatment also significantly increased bacterial burden in both the spleen and liver but had no effect on IFN-γ production. No role was found for CXCL16 in the production of antibody against SefA, a major surface antigen of S. enteritidis. Together, these results demonstrate a role for CXCL16 in the control of bacterial colonization of target organs and, more specifically, in the regulation of the cell-mediated arm of the primary response to S. enteritidis. |
Keywords: | Lymphocytes Animals Mice, Inbred BALB C Mice Salmonella enteritidis Salmonella Infections Chemokines, CXC Antibodies, Blocking Up-Regulation Female Receptors, Scavenger Chemokine CXCL10 Chemokine CXCL9 Chemokine CXCL11 Chemokine CXCL6 Interferon-gamma Chemokine CXCL16 |
Description: | Copyright © 2006, American Society for Microbiology |
DOI: | 10.1128/IAI.01065-06 |
Published version: | http://www.pubmedcentral.nih.gov/articlerender.fcgi?&pubmedid=16982830 |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.