Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/35530
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Restricted fetal growth and lung development: A morphometric analysis of pulmonary structure |
Author: | Lipsett, J. Tamblyn, M. Madigan, K. Roberts, P. Cool, J. Runciman, S. McMillen, I. Robinson, J. Owens, J. |
Citation: | Pediatric Pulmonology, 2006; 41(12):1138-1145 |
Publisher: | Wiley-Liss |
Issue Date: | 2006 |
ISSN: | 8755-6863 1099-0496 |
Statement of Responsibility: | Jill Lipsett, Michelle Tamblyn, Kellie Madigan, Pam Roberts, Johanna C. Cool, Susann I.C. Runciman, I. Caroline McMillen, Jeffrey Robinson, Julie A. Owens |
Abstract: | Intrauterine growth restriction (IUGR) in humans increases the risk of lung disease and impaired function suggesting that adverse intra-uterine conditions can alter lung development. We hypothesized that placental restriction (PR) of fetal growth would alter lung structure in late gestation. PR involved removal of implantation sites in pre-pregnant ewes. Normal (n = 7) and PR (n = 11) fetuses were delivered at day 140 gestation. Lungs were fixed by tracheal infusion, processed and analyzed by morphometry. PR reduced ponderal index (PI) of lambs by 13%, increased lung volume:body weight (BW) (19%), and decreased the proportion of lung volume that comprised parenchyma from 86.5(2.6)% to 76.7(2.1)% with no change in absolute volume of non-parenchyma. Within the parenchyma, PR increased the proportion comprising airspace from 42.0(2.2)% to 55.5(1.7)% with smaller (-13%) more dense (18%) airsacs/alveoli present. The overall effect was a reduction in total gas-exchange surface density (-10%). Lung wet-weight and volume, parenchymal volume, gas-exchange tissue, and airspace volumes and gas-exchange surface area correlated positively with BW and crown-rump length (CRL) for all animals. The relative lung weight and volume correlated negatively with BW, CRL, and lung weight:BW with PI. Lung weight, lung volume, parenchymal volume, airspace perimeter, percent of parenchymal gas-exchange tissue, gas-exchange surface density, and area correlated positively with PI. The results indicate increased sparing of lung growth but with increasing structural changes, predominantly within lung parenchyma, with increasing growth restriction. Structural alterations associated with PR and poor fetal growth may be important in the pathogenesis of impaired lung function associated with IUGR. |
Keywords: | Pulmonary hypoplasia growth development pathology morphometry IUGR |
Description: | © 2006 Wiley-Liss, Inc |
DOI: | 10.1002/ppul.20480 |
Published version: | http://dx.doi.org/10.1002/ppul.20480 |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.