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https://hdl.handle.net/2440/35674
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Type: | Conference paper |
Title: | The temporal profile of edema formation differs between male and female rats following diffuse traumatic brain injury |
Author: | O'Connor, C. Cernak, I. Vink, R. |
Citation: | Brain edema XIII / J.T. Hoff ... [et al.] (eds.): pp.121-124 |
Publisher: | Springer |
Publisher Place: | New York |
Issue Date: | 2006 |
Series/Report no.: | Acta neurochirurgica Supplement ; 96 |
ISBN: | 3211307125 9783211307120 |
ISSN: | 0065-1419 |
Conference Name: | International Symposium on Brain Edema and Tissue Injury (13th : 2005 : Ann Arbor, Mich.) |
Editor: | Hoff, J. Keep, R. Xi, G. Hua, Y. |
Statement of Responsibility: | C. A. O’Connor, I. Cernak, R. Vink |
Abstract: | Although female hormones are known to influence edema formation following traumatic brain injury (TBI), no studies have actually compared the temporal profile of edema formation in both male and female rats following diffuse TBI. In this study, male, female, and female ovariectomized rats were injured using the 2 m impact acceleration model of diffuse TBI. The temporal profile of brain water content was assessed over 1 week post-trauma. Male animals demonstrated increased (p < 0:05) edema at 5 hours, 24 hours, 3 days, 4 days, and 5 days after TBI with a peak at 5 hours post-injury. This time point was associated with increased blood-brain barrier (BBB) permeability. In contrast, intact females showed increased levels of edema (p < 0:05) at 5 hours, 24 hours, 3 days, and 4 days post-TBI, with a peak at 24 hours. No BBB opening was present in intact females at 5 hours. Female animals demonstrated more edema than male animals at 24 hours, but less at 5 hours, 3 days, and 5 days. Ovariectomy produced an edema profile that was similar to that observed in males. The temporal profile of edema formation after TBI seems to depend on endogenous hormone levels, a difference which may have an influence on clinical management. |
Keywords: | Blood-Brain Barrier Animals Rats Rats, Sprague-Dawley Brain Edema Brain Injuries Disease Models, Animal Ovariectomy Sex Factors Time Factors Female Male |
Rights: | © 2006 Springer-Verlag/Wien |
DOI: | 10.1007/3-211-30714-1_27 |
Published version: | http://dx.doi.org/10.1007/3-211-30714-1_27 |
Appears in Collections: | Aurora harvest 6 Pathology publications |
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