Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/3869
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Parker, D. | - |
dc.contributor.author | Hennian, E. | - |
dc.contributor.author | Marino, V. | - |
dc.contributor.author | de la Lande, I. | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | Archives of Oral Biology, 1999; 44(5):391-394 | - |
dc.identifier.issn | 0003-9969 | - |
dc.identifier.issn | 1879-1506 | - |
dc.identifier.uri | http://hdl.handle.net/2440/3869 | - |
dc.description.abstract | The effects of adrenaline on the release of noradrenaline from sympathetic nerves in human dental pulp in vitro were examined. Sympathetic nerves were stimulated at 5 Hz for 100 sec following incubation of pulp with [3H]noradrenaline (0.6 micromol/l). In the presence of desipramine (DMI, 0.3 micromol/l), adrenaline (0.1 and 1.0 micromol/l) inhibited the release of [3H]noradrenaline, an effect which was inhibited by the alpha2-adrenoceptor antagonist rauwolscine (0.1 micromol/l) and by the alpha2-adrenoceptor agonist UK 14,304 (0.1 micromol/l). The release of [3H]noradrenaline was unaffected by adrenaline (0.001 and 0.01 micromol/l) in the presence of DMI and DMI plus rauwolscine. Although presynaptic inhibitory alpha2- and facilitatory beta-adrenoceptors are present on sympathetic nerves in human dental pulp, these results imply that adrenaline activates only the inhibitory alpha2-receptors. | - |
dc.description.statementofresponsibility | D.A.S Parker, E Hennian, V Marino, I.S de la Lande | - |
dc.language.iso | en | - |
dc.publisher | Pergamon | - |
dc.rights | © 1999 Elsevier Science Ltd. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/s0003-9969(99)00015-1 | - |
dc.subject | Human dental pulp | - |
dc.subject | Sympathetic nerves | - |
dc.subject | Noradrenaline | - |
dc.subject | Adrenaline | - |
dc.subject | α2- and β-presynaptic adrenoceptors | - |
dc.title | Inhibitory effects of adrenaline on the release of noradrenaline from sympathetic nerves in human dental pulp | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0003-9969(99)00015-1 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 6 Dentistry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.