Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/40174
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kamil, R. | - |
dc.contributor.author | Geier, M. | - |
dc.contributor.author | Butler, R. | - |
dc.contributor.author | Howarth, G. | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Digestive Diseases and Sciences, 2007; 52(5):1247-1252 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.issn | 1573-2568 | - |
dc.identifier.uri | http://hdl.handle.net/2440/40174 | - |
dc.description | The original publication can be found at www.springerlink.com | - |
dc.description.abstract | Lactobacillus rhamnosus GG (LGG) and Bifidobacterium lactis Bb12 (Bb12) were assessed for their potential to prevent indomethacin-induced ulceration in the small intestine of Sprague-Dawley rats. Rats were gavaged skim milk, LGG, or Bb12 twice daily for 14 days. Between days 7–14, rats were gavaged indomethacin (Indo; 6 mg/kg). At sacrifice, small intestine was scored for ulceration and sampled for histologic, immunohistochemical, and myeloperoxidase (MPO) analyses. Indo+LGG-treated rats exhibited a 2.3-fold increase in MPO activity and a 9.8-fold increase in ulceration area compared to Indo-treated controls; these parameters did not differ significantly between Indo+Bb12 and Indo-treated controls. Crypt cell apoptosis decreased by 82% in Indo+Bb12-treated and 55% in Indo+LGG-treated rats compared to Indo-treated controls. Proliferation increased by 209% in Indo+LGG-treated animals compared to Indo-treated controls. Bb12 did not reduce indomethacin-induced intestinal ulceration, whereas LGG actually increased some indicators of injury. LGG and Bb12, at the doses tested, cannot alleviate indomethacin-induced intestinal injury. | - |
dc.description.statementofresponsibility | Rasha Kamil, Mark S. Geier, Ross N. Butler and Gordon S. Howarth | - |
dc.language.iso | en | - |
dc.publisher | Kluwer Academic/Plenum Publ | - |
dc.source.uri | http://dx.doi.org/10.1007/s10620-006-9443-3 | - |
dc.subject | Intestine, Small | - |
dc.subject | Animals | - |
dc.subject | Rats | - |
dc.subject | Rats, Sprague-Dawley | - |
dc.subject | Bifidobacterium | - |
dc.subject | Intestinal Diseases | - |
dc.subject | Peptic Ulcer | - |
dc.subject | Disease Models, Animal | - |
dc.subject | Indomethacin | - |
dc.subject | Peroxidase | - |
dc.subject | Apoptosis | - |
dc.subject | Cell Proliferation | - |
dc.subject | Probiotics | - |
dc.subject | Male | - |
dc.subject | Lacticaseibacillus rhamnosus | - |
dc.title | Lactobacillus rhamnosus GG exacerbates intestinal ulceration in a model of indomethacin-induced enteropathy | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/s10620-006-9443-3 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Howarth, G. [0000-0001-6979-6084] | - |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.