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Type: Journal article
Title: Quality of life in HCV-infection: lack of association with ALT levels
Author: Miller, E.
Hiller, J.
Citation: Australian and New Zealand Journal of Public Health, 2001; 25(4):355-361
Publisher: Public Health Assoc Australia Inc
Issue Date: 2001
ISSN: 1326-0200
Statement of
Emma R. Miller, Janet E. Hiller and David R. Shaw
Abstract: Objectives: To examine the impact of HCV infection in an Australian clinic population and identify the relationships between morbidity, psychosocial variables and one clinical indicator of HCV activity, alanine aminotransferase (ALT). Method: Ninety-five untreated HCV-infected patients (21-69 years) in infectious and liver diseases clinics who were all positive for HCV-RNA and had no significant comorbidities or coinfections completed a survey containing the Short Form 36 (SF36), as well as the six-item Social Support Questionnaire (SSQ6), demographic items and questions concerning respondents’ perceptions of their mode and duration of infection. Nine volunteers from this group participated in semi-structured qualitative interviews aimed at exploring the social impact of HCV status. These data were compared with serum ALT levels. SF36 scores were compared to population norms and according to participant variables. Results: Mean SF36 scores were significantly lower, across all modalities, than population norms. SF36 scores differed significantly according to age, sex, mode of infection, alcohol and methadone use, and satisfaction with social support. They did not differ significantly according to perceived or actual ALT level or pattern of ALT activity. Worry about ALT was prevalent (>50%) and this was independent of perceived ALT level. Conclusions and implications: HCVinfection is associated with significantly reduced quality of life and includes the perception of substantial social discrimination. ALT levels are of limited usefulness in ascertainment of a person’s sense of wellbeing and quality of life in HCV-infection. Increased support and information for affected individuals and measures aimed at countering social discrimination are important recommendations of the current study.
Keywords: Humans
Hepatitis C
Disease Progression
Alanine Transaminase
Sickness Impact Profile
Quality of Life
Social Support
Middle Aged
Surveys and Questionnaires
Description: © Public Health Association of Australia
DOI: 10.1111/j.1467-842X.2001.tb00594.x
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