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https://hdl.handle.net/2440/4158
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Type: | Journal article |
Title: | An international case-control study of adult glioma and meningioma: the role of head trauma. |
Author: | Preston-Martin, S. Pogoda, J. Schlehofer, B. Blettner, M. Howe, G. Ryan, P. Menegoz, F. Giles, G. Rodvall, Y. Choi, N. Little, J. Arslan, A. |
Citation: | International Journal of Epidemiology, 1998; 27(4):579-586 |
Publisher: | OXFORD UNIV PRESS |
Issue Date: | 1998 |
ISSN: | 0300-5771 1464-3685 |
Statement of Responsibility: | Susan Preston-Martin, Janice M Pogoda, Brigitte Schlehofer, Maria Blettner, Geoffrey R Howe, Philip Ryan, F Menegoz, Graham G Giles, Ylva Rodvall, N W Choi, Julian Little and Annie Arslan |
Abstract: | <h4>Background</h4>Increased brain tumour risk after head trauma suggested by case reports and clinical series has been previously studied epidemiologically with mixed results. An international multicentre case-control study investigated the role of head trauma from injury or sports participation in adult brain tumour risk.<h4>Methods</h4>In all, 1178 glioma and 330 meningioma cases were individually or frequency matched to 2236 controls. Only exposures that occurred at least 5 years before diagnosis and head injuries that received medical attention were considered.<h4>Results</h4>Risk for ever having experienced a head injury was highest for male meningiomas (odds ratio [OR] = 1.5, 95% confidence interval [CI] : 0.9-2.6) but was lower for 'serious' injuries, i.e. those causing loss of consciousness, loss of memory or hospitalization (OR = 1.2, 95% CI: 0.6-2.3). Among male meningiomas, latency of 15 to 24 years significantly increased risk (OR = 5.4, 95% CI: 1.7-16.6), and risk was elevated among those who participated in sports most correlated with head injury (OR = 1.9, 95% CI: 0.7-5.3). Odds ratios were lower for male gliomas (OR = 1.2, 95% CI : 0.9-1.5 for any injury; OR = 1.1, 95% CI: 0.7-1.6 for serious injuries) and in females in general.<h4>Conclusions</h4>Evidence for elevated brain tumour risk after head trauma was strongest for meningiomas in men. Findings related to sports should be interpreted cautiously due to cultural variability in our data and our lack of complete data on physical exercise in general which appeared to be protective. |
Keywords: | Humans Glioma Meningioma Brain Neoplasms Meningeal Neoplasms Craniocerebral Trauma Athletic Injuries Risk Factors Case-Control Studies Adult Aged Middle Aged Female Male |
DOI: | 10.1093/ije/27.4.579 |
Published version: | http://dx.doi.org/10.1093/ije/27.4.579 |
Appears in Collections: | Aurora harvest 6 Public Health publications |
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