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Type: Journal article
Title: Phylogenetic relationships of human populations in sub-Saharan Africa
Author: Weber, W.
Nash, D.
Motulsky, A.
Henneberg, M.
Crawford, M.
Martin, S.
Goldsmid, J.
Spedini, G.
Glidewell, S.
Schanfield, M.
Citation: Human Biology (Detroit): the international journal of population biology and genetics, 2000; 72(5):753-772
Publisher: Wayne State Univ Press
Issue Date: 2000
ISSN: 0018-7143
Abstract: This study utilizes the GM/KM immunoglobulin allotype system to elucidate the phylogenetic relationships of sub-Saharan Africans. The importance of understanding the relatedness of these peoples stems from the sub-Saharan region being the possible birthplace of humans. Haplotype distributions were determined for 19 populations and compared using chi-square analysis. Published data of other sub-Saharan Africans and representative populations worldwide were also added for comparison. Genetic distances between populations were calculated based on haplotype frequencies, and genetic relationships were observed through principal components analysis. Data from the GM/KM system showed a genetic homogeneity of the Bantu populations, with some exceptions, supporting the possibility of a common origin of these peoples. The Malagasy appeared as a divergent population, most likely due to Southeast Asian/Austronesian admixture, as indicated by the presence of the GM*AF B haplotype. The Cape Coloured also showed a divergence, with their genetic structures containing Caucasoid and Khoisan contributions. Finally, the Mbuti Pygmies appeared genetically isolated and had the highest frequency of the GM*A B haplotype out of all studied populations.
Keywords: Humans
Immunoglobulin Gm Allotypes
Factor Analysis, Statistical
Chi-Square Distribution
Gene Frequency
Gene Pool
Africa South of the Sahara
Immunoglobulin Km Allotypes
Genetic Variation
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