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https://hdl.handle.net/2440/4194
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DC Field | Value | Language |
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dc.contributor.author | Nasrin, D. | en |
dc.contributor.author | Collignon, P. J. | en |
dc.contributor.author | Wilson, E. J. | en |
dc.contributor.author | Pilotto, Louis Stanley John | en |
dc.contributor.author | Douglas, R. M. | en |
dc.date.issued | 1999 | en |
dc.identifier.citation | Journal of Paediatrics and Child Health, 1999; 35(6):558-561 | en |
dc.identifier.issn | 1034-4810 | en |
dc.identifier.uri | http://hdl.handle.net/2440/4194 | - |
dc.description | Copyright © 1999-2009 John Wiley & Sons | en |
dc.description.abstract | Objective: To determine the level of antibiotic resistance in pneumoniae (S. pneumoniae) isolated from nasal swabs of healthy children. Method: Cross-sectional community survey. Setting: Survey was undertaken in general practice settings in Canberra during March and April 1998. Subjects: Four hundred and sixty-one children under 3 years of age enrolled in a general practice trial of clinical practice guidelines for antibiotic use. Outcome measures: Resistance to penicillin, erythromycin, co-trimoxazole, tetracycline, chloramphenicol and cefotaxime among the isolates of S. pneumoniae. Results: A total of 461 nasal swabs were collected and S. pneumoniae was isolated from 171 (37.1%). Penicillin resistance was found in 12.3% of these isolates, with high level resistance in 0.6%. Resistance rates were higher for cotrimoxazole (44.4%) and erythromycin (18.1%) than for penicillin. Multidrug resistance was found in 19% of these isolates. There was a significant association between the attendance at a day care centre and carriage of pneumococcus (53%vs 32%, odds ratio (OR) 2.4, 95% confidence interval (CI)1.5–3.7, P < 0.001). Children who attended day care centres and had received antibiotics during the 4 months prior to swab collection were three times more likely to carry an antibiotic-resistant isolate than children who had neither attended a day care centre nor received antibiotics (68%vs 40%, OR 3.1, 95% CI 1.2–8.4, P = 0.02). Conclusion: The level of antibiotic resistance in pneumococci from healthy children was of concern. Carriage of pneumococcus was significantly higher in children who attended a day care centre. Resistance was significantly correlated with antibiotic use in combination with day-care attendance. These findings warrant more judicious use of antibiotics in children. | en |
dc.language.iso | en | en |
dc.title | Antibiotic resistance in Streptococcus pneumoniae isolated from children | en |
dc.type | Journal article | en |
dc.identifier.doi | 10.1046/j.1440-1754.1999.00416.x | en |
Appears in Collections: | Public Health publications |
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