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Type: Journal article
Title: Mapping platypus SOX genes; autosomal location of SOX9 excludes it from sex determining role
Author: Wallis, M.
Delbridge, M.
Pask, A.
Alsop, A.
Grutzner, F.
O'Brien, P.
Rens, W.
Ferguson-Smith, M.
Graves, J.
Citation: Cytogenetic and Genome Research, 2007; 116(3):232-234
Publisher: Karger
Issue Date: 2007
ISSN: 1424-8581
Statement of
M.C. Wallis, M.L. Delbridge, A.J. Pask, A.E. Alsop, F. Grützner, P.C.M. O'Brien, W. Rens, M.A. Ferguson-Smith, J.A.M. Graves
Abstract: In the absence of an SRY orthologue the platypus sex determining gene is unknown, so genes in the human testis determining pathway are of particular interest as candidates. SOX9 is an attractive choice because SOX9 deletions cause male-to-female sex reversal in humans and mice, and SOX9 duplications cause female-to-male sex reversal. We have localized platypus SOX9, as well as the related SOX10, to platypus chromosomes 15 and 10, respectively, the first assignments to these platypus chromosomes, and the first comparative mapping markers from human chromosomes 17 and 22. The autosomal localization of platypus SOX9 in this study contradicts the hypothesis that SOX9 acts as the sex determining switch in platypus.
Keywords: Chromosomes, Artificial, Bacterial; Chromosomes, Mammalian; Animals; Platypus; DNA-Binding Proteins; High Mobility Group Proteins; Transcription Factors; Chromosome Painting; Physical Chromosome Mapping; SOXE Transcription Factors; SOX9 Transcription Factor; Sex Determination Processes
RMID: 0020070326
DOI: 10.1159/000098192
Appears in Collections:Molecular and Biomedical Science publications
Environment Institute Leaders publications

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