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Type: Journal article
Title: Therapeutic drug monitoring of once daily tobramycin in cystic fibrosis - caution with trough concentrations
Author: Coulthard, K.
Peckham, D.
Conway, S.
Smith, C.
Bell, J.
Turnidge, J.
Citation: Journal of Cystic Fibrosis, 2007; 6(2):125-130
Publisher: Elsevier BV
Issue Date: 2007
ISSN: 1569-1993
Statement of
Kingsley P. Coulthard, Daniel G. Peckham, Steven P. Conway, Carol A. Smith, Jan Bell and John Turnidge
Abstract: <h4>Background</h4>: Once daily intravenous aminoglycoside dosing (ODD) is widely used to treat acute Pseudomonas aeruginosa exacerbations in patients with cystic fibrosis. Controversy exists as to what is the most appropriate method of therapeutic drug monitoring (TDM) of such therapy with recommendations including trough plasma concentrations of <1 mg/L or <2 mg/L, area under curve (AUC) and various nomograms. This study aimed to compare the exposures to ODD of tobramycin in adults and children with cystic fibrosis using the AUC and trough TDM approaches.<h4>Methods</h4>: Using a mono-exponential software program to calculate AUC from 2 plasma concentrations, AUCs were determined in 22 adults with pre-dose tobramycin concentrations <1 mg/L. The exposure of 5 children with reduced tobramycin clearances was simulated at the usual recommended dose of 10 mg/kg/daily but retaining a trough <1 mg/L.<h4>Results</h4>: A tobramycin dose of 10 mg/kg of tobramycin in these patients with normal serum creatinine and a trough concentration <1 mg/L resulted in exposures in excess of those associated with conventional 8-hourly dosing.<h4>Conclusions</h4>: The TDM approach of a trough <1 mg/L, as used with conventional 8-hourly tobramycin dosing, is not relevant to ODD.
Keywords: Sputum; Humans; Pseudomonas Infections; Cystic Fibrosis; Tobramycin; Anti-Bacterial Agents; Drug Monitoring; Infusions, Intravenous; Injections, Intravenous; Drug Administration Schedule; Area Under Curve; Adolescent; Adult; Child; Female; Male
Description: Copyright © 2006 European Cystic Fibrosis Society Published by Elsevier B.V.
RMID: 0020070490
DOI: 10.1016/j.jcf.2006.05.015
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Appears in Collections:Pathology publications

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