Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: IFNγ differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract
Other Titles: IFNgamma differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract
Author: Burman, A.
Banovic, T.
Kuns, R.
Clouston, A.
Stanley, A.
Morris, E.
Rowe, V.
Bofinger, H.
Skoczylas, R.
Raffelt, N.
Fahy, O.
McColl, S.
Engwerda, C.
Mcdonald, K.
Hill, G.
Citation: Blood, 2007; 110(3):1064-1072
Publisher: Amer Soc Hematology
Issue Date: 2007
ISSN: 0006-4971
Statement of
Angela C. Burman, Tatjana Banovic, Rachel D. Kuns, Andrew D. Clouston, Amanda C. Stanley, Edward S. Morris, Vanessa Rowe, Helen Bofinger, Renae Skoczylas, Neil Raffelt, Olivier Fahy, Shaun R. McColl, Christian R. Engwerda, Kelli P. A. McDonald, and Geoffrey R. Hill
Abstract: Although proinflammatory cytokines are key mediators of tissue damage during graft-versus-host disease (GVHD), IFNgamma has previously been attributed with both protective and pathogenic effects. We have resolved this paradox by using wild-type (wt), IFNgamma(-/-), and IFNgammaR(-/-) mice as donors or recipients in well-described models of allogeneic stem cell transplantation (SCT). We show that donor-derived IFNgamma augments acute GVHD via direct effects on (1) the donor T cell to promote T helper 1 (Th1) differentiation and (2) the gastrointestinal (GI) tract to augment inflammatory cytokine generation. However, these detrimental effects are overwhelmed by a protective role of IFNgamma in preventing the development of idiopathic pneumonia syndrome (IPS). This is the result of direct effects on pulmonary parenchyma to prevent donor cell migration and expansion within the lung. Thus, IFNgamma is the key cytokine differentially controlling the development of IPS and gastrointestinal GVHD after allogeneic SCT.
Keywords: Gastrointestinal Tract
Th1 Cells
Mice, Inbred BALB C
Mice, Knockout
Gastrointestinal Diseases
Graft vs Host Disease
Acute Disease
Stem Cell Transplantation
Transplantation, Homologous
Cell Differentiation
Cell Movement
Description: Copyright © 2007 by American Society of Hematology
Provenance: Prepublished online April 20, 2007
DOI: 10.1182/blood-2006-12-063982
Published version:
Appears in Collections:Aurora harvest 6
Molecular and Biomedical Science publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.