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Type: Journal article
Title: Maternal nutrient restriction in early pregnancy programs hepatic mRNA expression of growth-related genes and liver size in adult male sheep
Author: Hyatt, M.
Gopalakrishnan, G.
Bispham, J.
Gentili, S.
McMillen, I.
Rhind, S.
Rae, M.
Kyle, C.
Brooks, A.
Jones, C.
Budge, H.
Walker, D.
Stephenson, T.
Symonds, M.
Citation: Journal of Endocrinology, 2007; 192(1):87-97
Publisher: Soc Endocrinology
Issue Date: 2007
ISSN: 0022-0795
Statement of
M A Hyatt, G S Gopalakrishnan, J Bispham, S Gentili, I C McMillen, S M Rhind, M T Rae, C E Kyle, A N Brooks, C Jones, H Budge, D Walker, T Stephenson and M E Symonds
Abstract: The liver is a major metabolic and endocrine organ of critical importance in the regulation of growth and metabolism. Its function is determined by a complex interaction of nutritionally regulated counter-regulatory hormones. The extent to which hepatic endocrine sensitivity can be programed in utero and whether the resultant adaptations persist into adulthood is unknown and was therefore the subject of this study. Young adult male sheep born to mothers that were fed either a control diet (i.e.100% of total live weight-maintenance requirements) throughout gestation or 50% of that intake (i.e. nutrient restricted (NR)) from 0 to 95 days gestation and thereafter 100% of requirements (taking into account increasing fetal mass) were entered into the study. All mothers gave birth normally at term, the singleton offspring were weaned at 16 weeks, and then reared at pasture until 3 years of age when their livers were sampled. NR offspring were of similar birth and body weights at 3 years of age when they had disproportionately smaller livers than controls. The abundance of mRNA for GH, prolactin, and IGF-II receptors, plus hepatocyte growth factor and suppressor of cytokine signaling-3 were all lower in livers of NR offspring. In contrast, the abundance of the mitochondrial protein voltage-dependent anion channel and the pro-apoptotic factor Bax were up regulated relative to controls. In conclusion, maternal nutrient restriction in early gestation results in adult offspring with smaller livers. This may be mediated by alterations in both hepatic mitogenic and apoptotic factors.
Keywords: Liver; Animals; Sheep; Hepatocyte Growth Factor; Intercellular Signaling Peptides and Proteins; Receptors, Prolactin; Receptor, IGF Type 2; Receptors, Somatotropin; RNA, Messenger; DNA Primers; Organ Size; Reverse Transcriptase Polymerase Chain Reaction; Food Deprivation; Gestational Age; Pregnancy; Female; Male; Suppressor of Cytokine Signaling Proteins; Animal Nutritional Physiological Phenomena; Prenatal Nutritional Physiological Phenomena
Rights: Copyright © 2007 Society for Endocrinology
RMID: 0020070388
DOI: 10.1677/joe.1.06801
Appears in Collections:Molecular and Biomedical Science publications

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