Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/45251
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Type: Journal article
Title: Post-translational control of chemokines: a role for decoy receptors?
Author: Comerford, I.
Nibbs, R.
Citation: Immunology Letters, 2005; 96(2):163-174
Publisher: Elsevier Science BV
Issue Date: 2005
ISSN: 0165-2478
1879-0542
Statement of
Responsibility: 
Iain Comerford and Robert J.B. Nibbs
Abstract: It is well-established that chemokines play a critical role in the orchestration of inflammation and immunity. Interactions between chemokines and their receptors are essential for the homing of specific subsets of leukocytes to their functional microenvironments. They also influence other diverse biological processes such as development, leukocyte activation, Th1/Th2 polarisation, tumour metastasis, angiogenesis, and HIV pathogenesis. However, despite their importance, only now are we beginning to understand the complex regulation brought to bear on these molecules. In this review, we discuss a number of these key chemokine regulators that exert their influence once these proteins have been synthesised. We examine (i) chemokine storage, release, and presentation, (ii) protease regulation, (iii) viral manipulation of host chemokines, and (iv) natural mammalian receptor antagonists. Principally, the growing evidence for a role for decoy receptors in the chemokine system is discussed. In particular, the potential decoy function of the 'silent' pro-inflammatory chemokine receptor D6 is described alongside two other candidate decoy receptor molecules, DARC, and CCX-CKR. Dissecting the biological and pathological function of these chemokine controllers will lead to a deeper understanding of chemokine regulation, and may reveal novel strategies to therapeutically modify the chemokine system.
Keywords: Animals
Humans
Glycosaminoglycans
Receptors, Chemokine
Chemokines
Protein Biosynthesis
Protein Processing, Post-Translational
Virus Physiological Phenomena
Description: Copyright © 2004 Elsevier B.V. All rights reserved.
DOI: 10.1016/j.imlet.2004.08.018
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/506020/description#description
Appears in Collections:Aurora harvest
Molecular and Biomedical Science publications

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