Please use this identifier to cite or link to this item:
Type: Journal article
Title: Etiologic theories of idiopathic scoliosis: the breaking of bilateral symmetry in relation to left-right asymmetry of internal organs right thoracic adolescent idiopathic scoliosis (AIS) and vertebrate evolution
Author: Burwell, R.
Dangerfield, P.
Freeman, B.
Aujla, R.
Cole, A.
Kirby, A.
Pratt, R.
Webb, J.
Moulton, A.
Citation: Studies in Health Technology and Informatics, 2006; 123:385-390
Publisher: IOS Press
Issue Date: 2006
ISSN: 0926-9630
Statement of
Burwell RG, Dangerfield PH, Freeman BJ, Aujla RK, Cole AA, Kirby AS, Pratt RK, Webb JK, Moulton A.
Abstract: In the search to understand the etiology and pathogenesis of adolescent idiopathic scoliosis (AIS) some workers have focused on mechanisms initiated in embryonic life including a disturbance of bilateral (left-right or mirror-image) symmetry highly conserved in vertebrates. The normal external bilateral symmetry of vertebrates results from a default process involving mesodermal somites. The normal internal asymmetry of the heart, major blood vessels, lungs and gut with its glands is also highly conserved among vertebrates. It results from the breaking of the initial bilateral symmetry by a binary asymmetry switch mechanism producing asymmetric gene expression around the embryonic node and/or in the lateral plate mesoderm. In the mouse this switch occurs during gastrulation by cilia driving a leftward flow of fluid and morphogen(s) at the embryonic node (nodal flow) that favors precursors of the heart, great vessels and viscera on the left. Based on the non-random laterality of thoracic AIS curves, the hypothesis is suggested that an anomaly of the binary asymmetry switch explains the excess of right/left thoracic AIS. Some support for this hypothesis is the prevalence of right and left scoliosis curve laterality associated with situs inversus. There is recent evidence that vertebrates within their bilateralised shell retain an archaic left-right asymmetric visceral body organization evident in thoracic and abdominal organs.
Keywords: Thoracic Vertebrae
Models, Theoretical
Postural Balance
United Kingdom
Appears in Collections:Aurora harvest
Orthopaedics and Trauma publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.