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Type: Journal article
Title: Toxocara canis larval excretory/secretory proteins impair eosinophil-dependent resistance of mice to Nippostrongylus brasiliensis
Author: Giacomin, P.
Cava, M.
Tumes, D.
Gauld, A.
Iddawela, D.
McColl, S.
Parsons, J.
Gordon, D.
Dent, L.
Citation: Parasite Immunology, 2008; 30(8):435-445
Publisher: Blackwell Science Ltd
Issue Date: 2008
ISSN: 0141-9838
Statement of
P. R. Giacomin, M. Cava, D. J. Tumes, A. D. Gauld, D. R. Iddawela, S. R. McColl, J. C. Parsons, D. L. Gordon and L. A. Dent
Abstract: Survival of parasitic helminths within a host requires immune evasion and excretory/secretory (ES) proteins may contribute to this process. Eosinophils are important effector cells in immunity of mice to the nematode Nippostrongylus brasiliensis and eosinophilic interleukin-5 transgenic (IL-5 Tg) mice are highly resistant to the earliest stages of primary infections. In contrast, Toxocara canis is largely resistant to eosinophils, with viable larvae encysted in tissues often surrounded by these and other leucocytes. The aim of this study was to investigate whether T. canis ES (TES) proteins inhibit eosinophil-dependent resistance to N. brasiliensis. Mouse serum pre-treated with TES had reduced capacity to mediate the adherence of leucocytes to N. brasiliensis infective-stage larvae (L3) and this correlated with reduced complement C3 deposition on the parasite. TES did not inhibit eosinophil survival or eotaxin-dependent eosinophil migration in vitro. Cellular inflammation and eosinophil degranulation in the skin in response to injection of L3 was also not impaired by TES. However, when TES was included with L3 in an inoculum given to IL-5 Tg mice, a greatly increased number of parasites migrated to the lung. This suggests that the early eosinophil-dependent resistance in these mice was suppressed, by mechanisms yet to be determined.
Keywords: Lung
Toxocara canis
Helminth Proteins
Immune Evasion
Description: Copyright © 2008 The Authors Journal compilation © 2008 Blackwell Publishing Ltd
Provenance: Published Online: 25 Apr 2008
DOI: 10.1111/j.1365-3024.2008.01040.x
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Appears in Collections:Aurora harvest 6
Molecular and Biomedical Science publications

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