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Type: Journal article
Title: B-vitamins reduce plasma levels of beta amyloid
Author: Flickera, L.
Martins, R.
Thomas, J.
Acres, J.
Taddei, K.
Vasikaran, S.
Norman, P.
Jamrozik, K.
Almeida, O.
Citation: Neurobiology of Aging, 2008; 29(2):303-305
Publisher: Elsevier Science Inc
Issue Date: 2008
ISSN: 0197-4580
Statement of
Leon Flicker, Ralph N. Martins, Jenny Thomas, John Acres, Kevin Taddei, Samuel D. Vasikaran, Paul Norman, Konrad Jamrozik, Osvaldo P. Almeida
Abstract: Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1–40 (Aβ40). We randomized 299 older men to treatment with 2 mg of folate, plus 25 mg of B6 and 400 μg of B12, or placebo. After 2 years of treatment the mean (S.E.) increase of Aβ40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of Aβ40 and have a role in the prevention of AD.
RMID: 0020082234
DOI: 10.1016/j.neurobiolaging.2006.10.007
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