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https://hdl.handle.net/2440/50625
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Type: | Journal article |
Title: | Small-Intestinal Manifestations of Dextran Sulfate Sodium Consumption in Rats and Assessment of the Effects of Lactobacillus fermentum BR11 |
Author: | Geier, M. Smith, C. Butler, R. Howarth, G. |
Citation: | Digestive Diseases and Sciences, 2009; 54(6):1222-1228 |
Publisher: | Kluwer Academic/Plenum Publ |
Issue Date: | 2009 |
ISSN: | 0163-2116 1573-2568 |
Statement of Responsibility: | Mark S. Geier, Cassie L. Smith, Ross N. Butler and Gordon S. Howarth |
Abstract: | The dextran sulfate sodium (DSS) colitis model has been utilized to screen for novel therapeutics for ulcerative colitis. Evidence suggests the small intestine may also be affected by DSS. We characterized the effects of DSS on the small intestine and assessed the potential for Lactobacillus fermentum BR11 to modify or normalize DSS-induced changes. Rats were allocated to three groups, Water + Vehicle, DSS + Vehicle, and DSS + L. fermentum BR11. BR11 was administered twice daily for 14 days. DSS (2%) was provided from days 7 to 14. Small-intestinal tissue was analyzed for sucrase activity, histology, and crypt cell proliferation. Increased ileum crypt depth and cell proliferation was observed in DSS-treated rats compared to controls (P < 0.05). BR11 normalized these parameters. While DSS predominantly induces colonic damage, minor morphological alterations were also detected in the distal small intestine. L. fermentum BR11 normalized these features. |
Keywords: | Animals Rats Rats, Sprague-Dawley Colitis Dextran Sulfate Dose-Response Relationship, Drug Probiotics Male Limosilactobacillus fermentum |
Description: | © Springer Science+Business Media, 2008 |
DOI: | 10.1007/s10620-008-0495-4 |
Published version: | http://dx.doi.org/10.1007/s10620-008-0495-4 |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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